Agents and Actions

, Volume 23, Issue 3–4, pp 170–172 | Cite as

Effects of phorbol ester, serine phospholipids, and calcium on histamine release from mast cells and basophils

  • T. M. Cunniffe
  • F. L. Pearce
Histamine Release


The effects of calcium, serine phospholipids and the phorbol ester tetradecanoylphorbolacetate (TPA), a known activator of protien kinase C, have been examined on mastocytes from different sources. A complex and differential interaction between these agents and histamine secretion was observed in human basophil leucocytes and in peritoneal mast cells from the rat, mouse and hamster. On this basis, the possible role of kinase C in histamine release is discussed.


Calcium Ester Serine Mast Cell Histamine 
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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • T. M. Cunniffe
    • 1
  • F. L. Pearce
    • 1
  1. 1.Department of ChemistryUniversity College LondonLondonUK

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