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Effect of the mast cell disruptor B.W. 48/80 on dietary atherosclerosis in the male rabbit

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Zusammenfassung

Mit Cholesterin ernährte Kaninchen, denen gleichzeitig Compound 48/80 injiziert wurde, wiesen gegenüber nur mit Cholesterinzusatz gefütterten Tieren geringere Atheromatose des Aortenbogens auf. Compound 48/80 rief auch eine Verminderung des Serumcholesteringehaltes hervor. Unter dem Einfluss von Compound 48/80 schien ein beschleunigter Abbau der atheromatösen Plaques einzusetzen bevor noch eine Verminderung des Serumcholesterins auftrat. Es wird vermutet, dass der Schutz von Compound 48/80 gegen die durch Diät erzeugte Atheromatose des Kaninchens auf einer Veränderung des arteriellen Glykosaminglykans beruht.

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Authors and Affiliations

  1. Department of Experimental Medicine, Faculty of Medicine, University of Chile, Santiago, Chile

    C. R. Douglas, R. Cisternas, A. Rosenkranz & A. E. Weinlaub

Authors
  1. C. R. Douglas
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  2. R. Cisternas
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  3. A. Rosenkranz
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  4. A. E. Weinlaub
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Douglas, C.R., Cisternas, R., Rosenkranz, A. et al. Effect of the mast cell disruptor B.W. 48/80 on dietary atherosclerosis in the male rabbit. Experientia 23, 68–69 (1967). https://doi.org/10.1007/BF02142275

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