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Entero-Hepatic circulation of 7α-3H-DHEA-35S-sulfate, 7α-3H-DHEA-14C-glucuronoside and free 7α-3H-DHEA in the human

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Zusammenfassung

Während DHEA-sulfat, welches man bei Versuchspersonen in das Duodenum infundiert hatte, die Darmwand fast ohne Hydrolyse und Metabolismus passierte, erfuhr DHEA-glucuronid eine weitgehende Hydrolyse und Rekonjugation. Freies DHEA wurde hier zu 14% metabolisiert, wobei 3β-Hydroxy-Steroide mit Schwefelsäure, 3α-Hydroxy-Steroide mit Glucuronsäure konjugiert wurden. In der Leber unterliegen DHEA-sulfat und -glucuronid einem direkten Metabolismus.

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Literatur

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Authors and Affiliations

  1. Universitäts-Frauenklinik Mainz, Germany

    P. Knapstein, F. Wendlberger & G. W. Oertel

  2. Chirurgische Universitätsklinik Homburg/Saar, Germany

    P. Knapstein, F. Wendlberger & G. W. Oertel

Authors
  1. P. Knapstein
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  2. F. Wendlberger
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  3. G. W. Oertel
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Additional information

These investigations were supported by the Deutsche Forschungsgemeinschaft, Bad Godesberg (Germany).

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Knapstein, P., Wendlberger, F. & Oertel, G.W. Entero-Hepatic circulation of 7α-3H-DHEA-35S-sulfate, 7α-3H-DHEA-14C-glucuronoside and free 7α-3H-DHEA in the human. Experientia 23, 480–481 (1967). https://doi.org/10.1007/BF02142189

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