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Solubility of the hypothalamic hormones TSH-releasing factor (TRF) and LH-releasing factor (LRF) in organic and alcoholic solvents

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Résumé

L'hormone hypothalamique TRF (TSH-releasing factor) est soluble dans l'alcool méthylique à 90%, partiellement soluble dans l'alcool méthylique absolu ou le chloroforme; TRF n'est pas soluble dans la pyridine. Le chlorure de méthylène (dichlorométhane) n'extrait pas le TRF d'une solution aqueuse (préparation hautement purifiée, 15000 U/mg). L'hormone hypothalamique LRF (LH-releasing factor) n'est pas soluble dans le chloroforme mais est soluble dans l'alcool méthylique absolu ou à 90%.

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Literatur

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Authors and Affiliations

  1. Department of Physiology, Baylor University College of Medicine, 77025, Houston, Texas, USA

    R. Burgus, M. S. Amoss & R. Guillemin

Authors
  1. R. Burgus
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  2. M. S. Amoss
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  3. R. Guillemin
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Additional information

Supported by U.S.P.H.S. research grants No. AM 08290.03, No. HD 02577.01, training grant No. GM 956.04; also No. FR 00254 to Common Research Computer Facility, Texas Medical Center.

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Burgus, R., Amoss, M.S. & Guillemin, R. Solubility of the hypothalamic hormones TSH-releasing factor (TRF) and LH-releasing factor (LRF) in organic and alcoholic solvents. Experientia 23, 417–418 (1967). https://doi.org/10.1007/BF02142149

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