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The metabolism of hexamethylphosphoramide and hexamethylthiophosphoramide

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  • Chimica. Biochimica. Biophysica
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Résumé

L'hexaméthylphosphoramide (I), un agent antispermatogénique efficient pour rongeurs, est dégradé par une succession de déméthylations (I → II → III → IV) pour inactifs metabolites. Le thio-analogue (V), à moins qu'il soit metabolisé (I), est inactif au cours d'un cheminement alternatif (V → VI → II).

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Authors and Affiliations

  1. Unit of Reproductive Pharmacology, University of Manchester, Manchester 13, England

    A. R. Jones & J. S. Bertram

Authors
  1. A. R. Jones
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  2. J. S. Bertram
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Additional information

This work was supported by grants from the Ford Foundation and the Wellcome Trust.

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Jones, A.R., Bertram, J.S. The metabolism of hexamethylphosphoramide and hexamethylthiophosphoramide. Experientia 24, 326–327 (1968). https://doi.org/10.1007/BF02140798

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  • DOI: https://doi.org/10.1007/BF02140798

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