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Annals of Vascular Surgery

, Volume 9, Issue 2, pp 135–139 | Cite as

Preliminary evaluation of a technique for inhibiting intimal hyperplasia: Implantation of a resorbable luminal collagen membrane

  • K. Craig Kent
  • Shinsuke Mii
  • Larry F. Brown
  • Toby Nagle
  • Ioannis V. Yannas
Original Articles

Abstract

Pharmacologic control of intimai hyperplasia has been attempted through oral and intravenous administration of smooth muscle cell inhibitors. We report a more direct method of altering arterial healing using a novel bioresorbable membrane that can be applied to the lumen of an artery or anastomosis following endarterectomy or vascular reconstruction. Following a standard balloon injury, the infrarenal aortas of 3 kg female New Zealand white rabbits were opened and a thin membrane composed of collagen/chondroitin 6-sulfate copolymer was sutured to the posterior wall of each artery. Animals were killed at intervals of up to 3 months. All arteries remained patent. By 24 hours the membrane had become infiltrated with fibrin and red blood cells. An inflammatory response ensued and by 8 days the membrane was filled with mononuclear cells. At 3 months only a small remnant of the membrane remained. Intimal hyperplasia developed throughout the injured aorta. However, the hyperplastic response beneath the membrane was no greater than that observed in the adjacent injured aorta. A bioresorbable membrane can be sutured into the lumen of a small-diameter vessel without inducing thrombosis and without locally increasing intimal hyperplasia. A prosthesis of this type might be used to deliver inhibitors of smooth muscle cell proliferation and migration to the injured arterial wall.

Keywords

Smooth Muscle Cell Zealand White Rabbit Intimal Hyperplasia Smooth Muscle Cell Proliferation Collagen Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Annals of Vascular Surgery Inc. 1995

Authors and Affiliations

  • K. Craig Kent
    • 1
  • Shinsuke Mii
    • 1
  • Larry F. Brown
    • 2
  • Toby Nagle
    • 3
  • Ioannis V. Yannas
    • 3
  1. 1.Department of SurgeryBeth Israel Hospital and Harvard Medical SchoolBoston
  2. 2.Department of PathologyBeth Israel Hospital and Harvard Medical SchoolBoston
  3. 3.Department of Mechanical EngineeringMassachusetts Institute of TechnologyBoston

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