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Antimalarial activity of natural, racemic and unnatural dihydroquinine, dihydroquinidine and their various racemic analogs in mice infected withPlasmodium berghei

Experientia volume 27, pages 1100–1101 (1971)Cite this article

Zusammenfassung

Racemisches Dihydrochinin und die beiden optischen Antipoden zeigen die gleiche Aktivität gegenPlasmodium berghei wie Chinin. Hingegen waren die entsprechenden Dihydrochinidine sowie die 6′-Desmethoxy-7′-chlor-Analogen von Dihydrochinin und Dihydrochinidin etwa viermal wirksamer.

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Literatur

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  4. The unnatural enantiomers of dihydroquinine and dihydroquinidine were first prepared byP. Rabe andA. Schultze, Ber. dt. chem. Ges.66, 120 (1933), but results on their antimalarial activity are not available.

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  6. Determination of LD50 was performed by Dr.W. Pool, Department of Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey, USA.

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Affiliations

  1. Chemical Research Division, Hoffmann-La Roche Inc., 07110, Nutley, New Jersey, USA

    A. Brossi, M. Uskoković, J. Gutzwiller, Antoniana U. Krettli & Z. Brener

  2. Instituto Nacional de Endemias Rurais, C.P. 1743

    A. Brossi, M. Uskoković, J. Gutzwiller, Antoniana U. Krettli & Z. Brener

  3. Department of Parasitology, University of Minas Gerais, Belo Horizonte, Brazil

    A. Brossi, M. Uskoković, J. Gutzwiller, Antoniana U. Krettli & Z. Brener

Authors
  1. A. Brossi
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  2. M. Uskoković
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  3. J. Gutzwiller
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  4. Antoniana U. Krettli
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  5. Z. Brener
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Brossi, A., Uskoković, M., Gutzwiller, J. et al. Antimalarial activity of natural, racemic and unnatural dihydroquinine, dihydroquinidine and their various racemic analogs in mice infected withPlasmodium berghei . Experientia 27, 1100–1101 (1971). https://doi.org/10.1007/BF02138906

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  • DOI: https://doi.org/10.1007/BF02138906

Keywords

  • Antimalarial Activity
  • Chinin
  • Dihydroquinidine
  • Racemic Analog
  • Dihydroquinine