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Additive and synergistic inhibition of mammalian microsomal enzyme functions by piperonyl butoxide, safrole and other methylenedioxyphenyl derivatives

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  • Pharmacologica
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Zusammenfassung

Piperonylbutoxyd, Methylendioxylanilin, Methyleugenol, Safranol und Vanillylamin bewirken eine additive Hemmung der Funktion mikrosomaler Enzyme in Mäusen, wenn sie zusammen in Dosen verabreicht werden, die einzeln inaktiv sind. Piperonylbutoxyd und Safranol induzieren synergistisch die Hemmung von Aminopyrenedemethylase-Aktivität. Es erfolgte keine synergistische Hemmung nach kombinierter Behandlung mit Pib. und hohen Dosen der strukturell verwandten, aber inaktiven Piperonylsäure.

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Literatur

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Author notes

  1. S. S. Epstein (Swetland Professor of Environmental Health and Human Ecology)

    Present address: School of Medicine, Case Western Reserve University, 44106, Cleveland, Ohio, USA

Authors and Affiliations

  1. Laboratories of Environmental Toxicology and Carcinogenesis and of Biostatistics, Children's Cancer Research Foundation, Inc., USA

    M. A. Friedman, E. Arnold, Y. Bishop &  S. S. Epstein (Swetland Professor of Environmental Health and Human Ecology)

  2. Department of Pathology, Harvard Medical School, USA

    M. A. Friedman, E. Arnold, Y. Bishop &  S. S. Epstein (Swetland Professor of Environmental Health and Human Ecology)

  3. Harvard School of Public Health, 35 Binney Street, 02115, Boston, Massachusetts, USA

    M. A. Friedman, E. Arnold, Y. Bishop &  S. S. Epstein (Swetland Professor of Environmental Health and Human Ecology)

Authors
  1. M. A. Friedman
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  2. E. Arnold
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  3. Y. Bishop
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  4. S. S. Epstein
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Additional information

Supported by N.I.H. Grants No. C-6516 and No. Fr-05526.

We thank Mrs.M. Sengupta and Mr.E. Greene for their technical assistance.

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Friedman, M.A., Arnold, E., Bishop, Y. et al. Additive and synergistic inhibition of mammalian microsomal enzyme functions by piperonyl butoxide, safrole and other methylenedioxyphenyl derivatives. Experientia 27, 1052–1054 (1971). https://doi.org/10.1007/BF02138875

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  • DOI: https://doi.org/10.1007/BF02138875

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