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Inhibition of cortisol metabolism in vitro by 2-methylnaphthoquinone (menadione): A possible interpretation of the potentiation of cortisol activity in vivo

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  • Chimica. Biochimica. Biophysica
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Résumé

Le degré de réduction du noyeau A du cortisole par les microsomes du foie du rat et par le NADPH est inhibé du 50% par le méthyle-2-naphtoquinone (ménadione). L'inhibition est partiellement allégée par l'addition de NADPH ce qui indique que la ménadione gêne la disponibilité du NADPH. En effet, il s'est trouvé que la ménadione active la diminution de NADPH par les microsomes du foie. Il est possible que l'augmentation précédemment signalée de l'activité pharmacologique du cortisole par la ménadione est apparentée à l'inhibition du métabolisme du cortisole.

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Authors and Affiliations

  1. Lederle Laboratories, Division of American Cyanamid, 10965, Pearl River, New York, USA

    D. Kupfer & Lucia Peets

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  1. D. Kupfer
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  2. Lucia Peets
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Kupfer, D., Peets, L. Inhibition of cortisol metabolism in vitro by 2-methylnaphthoquinone (menadione): A possible interpretation of the potentiation of cortisol activity in vivo. Experientia 24, 893–894 (1968). https://doi.org/10.1007/BF02138634

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  • DOI: https://doi.org/10.1007/BF02138634

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