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A kinetic model for nucleohistone-dependent DNA synthesis

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  • Chimica. Biochimica. Biophysica
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Résumé

A basse concentration de «template» et de déoxynucléoside triphosphate, la vitesse de synthèse de DNA par la DNA polymérase deE. coli suit la loi simple de Michaelis. Les valeurs deKm et deV pour les réactions dépendant de la nucléohistone sont plus basses que les valeurs pour les réactions dépendant du DNA, mais les rapportsV/Km sont semblables. Les additions supplémentaires de constituants du mélange réactionnel de la polymérase n'ont eu qu'un très faible effet sur le système dépendant de la nucléohistone.

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Author information

Authors and Affiliations

  1. Western Regional Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 94710, Albany, California

    S. Schwimmer

  2. Division of Biology, California Institute of Technology, Pasadena, California, USA

    S. Schwimmer

Authors
  1. S. Schwimmer
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Additional information

This work was conducted under a cooperative agreement between the Division of Biology, California Institute of Technology and the Western Utilization Research and Development Division, Agricultural Research Service, U.S. Department of Agriculture. The work was supported in part by U.S. Public Health Service Grants Nos. GM-03977, GM-05143, AM-03102.

Reference to a company or product name does not imply approval or recommendation of the product by the U.S. Department of Agriculture to the exclusion of others that may be suitable.

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Schwimmer, S. A kinetic model for nucleohistone-dependent DNA synthesis. Experientia 24, 887–888 (1968). https://doi.org/10.1007/BF02138630

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  • DOI: https://doi.org/10.1007/BF02138630

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