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d-5-Chloro-2-(α-hydroxybenzyl)benzimidazole and 1-Alkyl-5-chloro-2-(α-hydroxybenzyl)benzimidazoles as inhibitors of poliovirus multiplication

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  • Chimica. Biochimica. Biophysica
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Zusammenfassung

Died-isomere Verbindung ist verantwortlich für die Poliovirus-hemmende Aktivität vondl-5-Chlor-2-(α-oxy-benzyl)-benzimidazol.dl-1-Propyl-5-chlor-unddl-1-Butyl-5-chlor-Derivate sind ausserordentlich wirksam zur Verhinderung der Vermehrung der Typen 1, 2 und 3 des Poliovirus; andere 1-Alkyl-5-chlor-Derivate sind ebenfalls aktiv. Die 1-Alkyl-Grundverbindungen sind jedoch wirksamer als deren gleichartige 1-Alkyl-5-chlor-Derivate.

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References

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Authors and Affiliations

  1. Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, W.1, London, England

    D. G. O'Sullivan, Danica Pantic & A. K. Wallis

Authors
  1. D. G. O'Sullivan
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  2. Danica Pantic
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  3. A. K. Wallis
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Additional information

The research is supported by the National Fund for Research into Poliomyelitis and other Crippling Diseases.

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O'Sullivan, D.G., Pantic, D. & Wallis, A.K. d-5-Chloro-2-(α-hydroxybenzyl)benzimidazole and 1-Alkyl-5-chloro-2-(α-hydroxybenzyl)benzimidazoles as inhibitors of poliovirus multiplication. Experientia 24, 661–663 (1968). https://doi.org/10.1007/BF02138297

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  • DOI: https://doi.org/10.1007/BF02138297

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