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Therapy of chemically induced skin tumors of mice with vitamin a palmitate and vitamin a acid

  • Specialia
  • Anatomica, Histologica, Embryologica, Carcinologica
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Zusammenfassung

Mittels Dimethylbenzanthracen und Krotonöl wurden bei Mäusen Hautpapillome erzegut. Diese Tumoren wurden durch systemische Anwendung von Retinylpalmitat und Retinsäure therapeutisch beeinflusst. Es kam zu einer deutlichen Regression der Tumoren, die dosisabhängig war. Sowohl orale wie parenterale tägliche oder wöchentliche Applikation der geprüften Vitamin-A-Verbindungen waren wirksam. Der Wirkungsamechanismus wird diskutiert. Er unterscheidet sich grundsätzlich von demjenigen anderer tumorhemmender Substanzen.

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References

  1. E. W. Chu andR. A. Malmgren, Cancer Res.25, 884 (1965).

    CAS  Google Scholar 

  2. R. E. Davies, Cancer Res.27, 237 (1967).

    CAS  Google Scholar 

  3. H. McMichael, Cancer Res.25, 947 (1965).

    CAS  Google Scholar 

  4. N. H. Rowe andR. J. Gorlin, J. dent. Res.38, 72 (1959).

    Article  CAS  Google Scholar 

  5. U. Saffiotti, R. Montesano, A. R. Sellakumar andS. A. Borg, Cancer20, 857 (1967).

    Article  CAS  Google Scholar 

  6. D. Schmähl, personal communication.

  7. W. Bollag, Int. J. Vit. Res.40, 299 (1970).

    CAS  Google Scholar 

  8. W. Bollag, unpublished.

  9. I. Lasnitzki, Natn. Cancer Inst. Monograph12, 381 (1963).

    CAS  Google Scholar 

  10. J. T. Dingle, inLysosomes, CIBA Foundation Symposium (Little, Brown and Co., Boston 1963), p. 384.

    Book  Google Scholar 

  11. J. A. Lucy andJ. T. Dingle, Nature, Lond.204, 156 (1964).

    Article  CAS  Google Scholar 

  12. J. T. Dingle andJ. A. Lucy, Biol. Rev.40, 422 (1965).

    Article  CAS  Google Scholar 

  13. D. Brandes andE. Anton, Lab. Invest.15, 987 (1966).

    CAS  Google Scholar 

  14. E. Anton andD. Brandes, Expl molec. Path.7, 156 (1967).

    Article  CAS  Google Scholar 

  15. A. Studer, Schweiz. Z. allg. Path.13, 799 (1950).

    CAS  Google Scholar 

  16. A. Studer, Z. ges. exp. Med.121, 287 (1953).

    Article  CAS  Google Scholar 

  17. A. Studer andJ. R. Frey, Dermatologica104, 578 (1952).

    Google Scholar 

  18. E. Läuppi, unpublished.

  19. M. A. Lappé andR. T. Prehn, Cancer Res.29, 2374 (1969).

    Google Scholar 

  20. D. W. Dresser, Nature, Lond.217, 527 (1968).

    Article  CAS  Google Scholar 

  21. W. Bollag andF. Ott, Agents and Actions1, 172 (1970).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Experimental Medicine, F. Hoffmann-La Roche & Co. Ltd., CH-4002, Basel, Switzerland

    W. Bollag

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  1. W. Bollag
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Bollag, W. Therapy of chemically induced skin tumors of mice with vitamin a palmitate and vitamin a acid. Experientia 27, 90–92 (1971). https://doi.org/10.1007/BF02137759

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  • DOI: https://doi.org/10.1007/BF02137759

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