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Arginine-vasopressin, lysine-vasopressin, and oxytocin, C14-labeled in the glycine residue

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  • Chimica, Biochimica, Biophysica
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Zusammenfassung

Die Synthese von Arginin-Vasopressin, Lysin-Vasopressin und Oxytocin, deren Glycinrest eine14C-Markierung trägt, wird mit Hilfe der Festkörpermethode nachMerrifield beschrieben.

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Author information

Authors and Affiliations

  1. Department of Physiology, Mount Sinai Graduate and Medical Schools of the City University of New York, 5th Avenue and 100th Street, 10029, New York, N.Y., USA

    R. Walter & R. T. Havran

  2. Medical Research Center, Brookhaven National Laboratory, 11973, Upton, N. Y., USA

    R. Walter & R. T. Havran

Authors
  1. R. Walter
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  2. R. T. Havran
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Additional information

Supported by National Institutes of Health grants No. AM-13567 and No. AM-10080 and the Atomic Energy Commission.

Abbreviations follow the rules of the IUPAC-IUB Commission on Biochemical Nomenclature in Biochemistry5, 2485 (1966). All optically-active amino acids are ofl-configuration. The following additional abbreviations were used: N-hydroxysuccinimide ester (OSu), ethanol (EtOH), methanol (MeOH), acetic acid (AcOH),n-butanol (n-BuOH), pyridine (Pyr) and N,N′-dicyclohexylcarbodiimide (DCCI). Protected peptides and hormones were visualized on thinlayer plates according to the procedure byH. Zahn andE. Rexroth, Z. analyt. Chem.148, 181 (1955). The biological activities of the hormones were measured against the U.S.P. Posterior Pituitary Reference Standard; the four-point design was used for these bioassays and standard errors were calculated according to the method ofC. I. Bliss,The Statistics of Bioassay (Academic Press, New York, N.Y. 1952).

Acknowledgments. The authors wish to thank Mr.D. Schlesinger for some of the amino acid derivatives used, and MissM. Wahrenburg and Mrs.A. Silverman for bioassays.

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Walter, R., Havran, R.T. Arginine-vasopressin, lysine-vasopressin, and oxytocin, C14-labeled in the glycine residue. Experientia 27, 645–646 (1971). https://doi.org/10.1007/BF02136937

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