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Über die Hemmung des Gerinnungsfermentes Thrombin durch Benzamidinderivate

  • Specialia
  • Chimica. Biochimica. Biophysica
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Summary

A series of aminomethyl, guanidino and amidino derivatives of benzene were investigated for their inhibitory effect on the activity of thrombin. Amidines were generally more potent than the other compounds.p-Amidinophenylpyruvic acid, a strong trypsin inhibitor, was found also to be the strongest small-molecular inhibitor on the activity of thrombin.

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Authors and Affiliations

  1. Pharmakologisches Institut der Medizinischen Akademie Erfurt, DDR

    F. Markwardt & P. Walsmann

Authors
  1. F. Markwardt
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  2. P. Walsmann
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Markwardt, F., Walsmann, P. Über die Hemmung des Gerinnungsfermentes Thrombin durch Benzamidinderivate. Experientia 24, 25–26 (1968). https://doi.org/10.1007/BF02136769

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  • DOI: https://doi.org/10.1007/BF02136769

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