Summary
The action of Haloperidol on the content of dopamine and 3–4 dihydroxyphenylacetic acid (DOPAC) in the rat caudate nucleus has been examined. At doses which inhibit self-stimulation behaviour, dopamine remains unchanged, while DOPAC increases significantly. These results may be interpreted by the present theories relative to the mechanism of action of neuroleptic drugs.
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Literatur
Nous remercions le Dr.P. Janssen qui nous a fourni l'Halopéridol.
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Gérardy, J., Dresse, A. Action de l'Halopéridol sur le métabolisme oxydatif de la dopamine dans le noyau caudé du rat. Experientia 27, 1315 (1971). https://doi.org/10.1007/BF02136710
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DOI: https://doi.org/10.1007/BF02136710