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Locomotor activity and regional brain noradrenaline levels in rats treated with prenylamine

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Resumen

Ratas inyectadas con diferentes dosis de prenylamina (gluconato) presentaron una marcada disminución de la actividad motora espontánea y de los niveles de noradrenalina en el hipotálamo, tálamo y corteza cerebral, pero no en el tegmento del mesencéfalo. Se detectó una estrecha relación entre la caída de la concentración de NA hipotalámica y la disminución de la actividad espontanea con las diferentes dosis de prenylamina empleadas.

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Author information

Authors and Affiliations

  1. Laboratorio de Investigaciones Cerebrales, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Mendoza, Argentina

    Susana T. Broitman & A. O. Donoso

Authors
  1. Susana T. Broitman
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  2. A. O. Donoso
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Additional information

This work was supported in part by a grant from Hoetsch Laboratories. They also supplied us the drug Segontin® (prenylamine). A. O. D. is Associate Research of the Consejo Nacional de Investigaciones Cientificas y Técnicas de Argentina.

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Broitman, S.T., Donoso, A.O. Locomotor activity and regional brain noradrenaline levels in rats treated with prenylamine. Experientia 27, 1308–1309 (1971). https://doi.org/10.1007/BF02136705

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  • DOI: https://doi.org/10.1007/BF02136705

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