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The regulatory role of phosphodiesterase in adenosine cyclic 3′,5′-monophosphate mediated ACTH action

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  • Chimica, Biochimica, Biophysica
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Résumé

Le désoxycholate de soude inhibe fortement l'activité de la phosphodiestérase surrénalienne du rat. Par contre, l'administration de l'ACTH in vivo augmente cette activité en présence du déoxycholate. In vitro, chez le rat traité préalablement par le l'ACTH, cette activité est moins inhibée par le désoxycholate dans la fraction particulière comme dans la fraction surnageante. L'action de l'ACTH joue donc un rôle régulateur de la phosphodiestérase.

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Author notes

  1. S. S. Ng

    Present address: Department of Biochemistry, University of Rhode Island, 02881, Kingston, R.I., USA

Authors and Affiliations

  1. Department of Biology, Chung Chi College, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong

    S. S. Ng & Y. C. Kong

  2. Hormone Research Laboratory, University of California, 94122, San Francisco, Calif, USA

    Y. C. Kong

Authors
  1. S. S. Ng
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  2. Y. C. Kong
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Ng, S.S., Kong, Y.C. The regulatory role of phosphodiesterase in adenosine cyclic 3′,5′-monophosphate mediated ACTH action. Experientia 27, 1257–1258 (1971). https://doi.org/10.1007/BF02136671

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  • DOI: https://doi.org/10.1007/BF02136671

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