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Macromolecular hypertension: Hypertensive cardiovascular disease from subcutaneously administered polyvinyl alcohol

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Zusammenfassung

Nach subkutaner Injektion von Polyvinylalkohollösung entwickeln Ratten innerhalb eines Monats arteriellen Hochdruck. Gleichzeitig beobachtet man Vergrösserung von Leber, Milz, Herz und Nieren, sowie Thymusatrophie, jedoch keine Nebennierenvergrösserung. Es wird daher vermutet, dass diese Hypertonie, ähnlich der durch Methylcellulose hervorgerufenen, eine Folge von gestörter intraglomerulärer Durchblutung ist.

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References

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Authors and Affiliations

  1. The Carter Physiology Laboratory, University of Texas Medical Branch, Galveston, USA

    C. E. Hall & O. Hall

Authors
  1. C. E. Hall
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  2. O. Hall
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Additional information

This study was supported by grants H 2703 and H 4327 from the United States Public Health Service.

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Hall, C.E., Hall, O. Macromolecular hypertension: Hypertensive cardiovascular disease from subcutaneously administered polyvinyl alcohol. Experientia 18, 38–40 (1962). https://doi.org/10.1007/BF02136650

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