Summary
The cytotoxic methylhydrazine derivative procarbazine or Natulan® has a marked influence on the synthesis of deoxyribonucleic acid in Ehrlich ascites carcinoma cells. The incorporation of3H-thymidine into DNA — measured by autoradiographic methods — is inhibited.
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Rutishauser, A., Bollag, W. Untersuchungen über den Wirkungsmechanismus von Procarbazin (Natulan®). Experientia 23, 222–223 (1967). https://doi.org/10.1007/BF02136301
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DOI: https://doi.org/10.1007/BF02136301