Zusammenfassung
γ-Aminobuttersäure (GABA) vermindert die Impulsfrequenz der spontan-aktiven Nervenzellen beim Insekt. Wirksame Konzentrationen betragen 0,1–25 · 10−4 M. Ein unerwartetes Ergebnis war die Beobachtung, dass nach Applikation von GABA eine Erhöhung der Impulsfrequenz vor der Verminderung stattfindet.
Literatur
J. Awapara, A. J. Landua, R. Fuerst andB. Seale, J. biol. Chem.187, 35 (1950).
E. Roberts andS. Frankel, J. biol. Chem.187, 55 (1950).
S. W. Kuffler andC. Edwards, J. Neurophysiol.21, 589 (1958).
K. A. C. Elliott andH. H. Jasper, Physiol. Rev.39, 383 (1959).
P. N. R. Usherwood andH. Grundfest, J. Neurophysiol.28, 497 (1965).
S. M. Vereshtchagin, I. A. Sytinsky andV. P. Tyshchenko, J. Insect Physiol.6, 21 (1961).
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This investigation was supported in part by the NSF College Teacher Research Participation Program, Grant No. GY-682, and by NSF Undergraduate Research Participation Program, Grant No. GY-151. — We thank Mr.A. McAfee, our undergraduate participant, for his assistance in this investigation.
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Sittler, O.D., DeRemer, R.J. Gamma aminobutyric acid induced changes in the spontaneous firing rates of insect neurons. Experientia 23, 284–285 (1967). https://doi.org/10.1007/BF02135689
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DOI: https://doi.org/10.1007/BF02135689