Experientia

, Volume 23, Issue 4, pp 261–262 | Cite as

Enhancement of fibrinolysis and thrombolysis by polysorbate 80 (Tween 80®)

  • H. C. Kwaan
  • P. Brakman
  • T. Astrup
Specialia

Keywords

Urokinase Polysorbate 

Zusammenfassung

Polysorbate 80 (Tween 80®), eine polyhydroxyle, nicht-ionisierbare, oberflächenaktive Substanz, vermindert die Adsorption von Urokinase an Glas, erhöht deren fibrinolytische Aktivität in vitro und steigert ihre thrombolytische Wirkung in experimentell hervorgerufenen Thrombosen im Kaninchen.

Literatur

  1. 1.
    T. Astrup andS. Müllertz, Archs Biochem. Biophys.40, 346 (1952).Google Scholar
  2. 2.
    K. N. von Kaulla, inChemistry of Thrombolysis: Human Fibrinolytic Enzymes (Charles C. Thomas, Springfield, Illinois 1963), p. 261.Google Scholar
  3. 3.
    T. Astrup andN. Alkjaersig, Nature168, 565 (1951).Google Scholar
  4. 4.
    M. N. Richard andB. E. Sanders, Can. J. Biochem. Physiol.41, 211 (1963).PubMedGoogle Scholar
  5. 5.
    P. Brakman, P. Klug andT. Astrup, Thromb. Diath. haemorrh.11, 234 (1964).PubMedGoogle Scholar
  6. 6.
    M. Lassen, Scand. J. clin. Lab. Invest.10, 384 (1958).PubMedGoogle Scholar
  7. 7.
    K. Magnus, J. Guld, H. Waaler andM. Magnusson, Am. Rev. Tuberc. pulm. Dis.74, 297 (1956).Google Scholar
  8. 7a.
    H. Waaler, J. Guld, K. Magnus andM. Magnusson, Bull. Wld Hlth Org.19, 783 (1958).Google Scholar
  9. 8.
    Ch. H. Lack andS. Y. Ali, Nature201, 1030 (1964).PubMedGoogle Scholar
  10. 9.
    E. E. Cliffton andA. R. Burchell, Thromb. Diath. haemorrh.5, 463 (1961).Google Scholar
  11. 10.
    H. C. Kwaan andT. Astrup, Circulation Res.17, 477 (1965).PubMedGoogle Scholar
  12. 11.
    N. Back, A. E. Munson, B. R. Munson, H. B. Lassman, C. M. Ambrus andJ. L. Ambrus, Fedn Proc. Fedn Am. Socs exp. Biol.24, Abstract No. 1432, 387 (1965).Google Scholar

Copyright information

© Birkhäuser Verlag 1967

Authors and Affiliations

  • H. C. Kwaan
    • 1
  • P. Brakman
    • 1
  • T. Astrup
    • 1
  1. 1.The James F. Mitchell Foundation, Institute for Medical ResearchWashington D.C.USA

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