Abstract
Previous studies from the authors' laboratory using the biodegradable anastomotic ring (BAR) have demonstrated the safety of this device in animals irradiated preoperatively with the equivalent of 5000 rad; sutured, stapled, and BAR anastomoses all had leak rates of 10 percent or less in this setting. This study was undertaken to assess the safety of the BAR after irradiation with the equivalent of 6000 rad. Thirteen mongrel dogs underwent preoperative irradiation to the rectum and rectosigmoid, receiving 6000 rad according to the nominal standard dose equation. After a three-week rest period, each dog underwent anterior resection of the rectosigmoid and anastomosis with the BAR. The anastomoses were evaluated for early and late healing and anastomotic leaks. The results were compared with previous data from the authors' laboratory using an identical model. Radiographic leaks were found in 7 of 10 sutured anastomoses, 8 of 10 stapled anastomoses, and 3 of 13 BAR anastomoses (P < 0.01). Comparative clinical leaks were 5 of 10 for sutured, 5 of 10 for stapled, and 3 of 13 for BAR anastomoses. These data suggest that the BAR may offer added safety to an anastomosis after preoperative irradiation. Whether this effect is due to the atraumatic technique of placing the device, improved blood flow to the anastomotic margins, or other factors, is still undetermined.
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Smith AD, Bubrick MP, Mestitz ST, et al. Evaluation of the biofragmentable anastomotic ring following preoperative irradiation to the rectosigmoid in dogs. Dis Colon Rectum 1988;31:5–9.
Schauer RM, Bubrick MP, Feeney DA, et al. Effects of low-dose preoperative irradiation on low anterior anastomosis in dogs. Dis Colon Rectum 1982;25:401–5.
Bubrick MP, Rolfsmeyer ES, Schauer RM, et al. Effects of highdose and low-dose preoperative irradiation on low anterior anastomoses in dogs. Dis Colon Rectum 1982;25:406–15.
Blake DP, Bubrick MP, Kochsiek GG, et al. Low anterior anastomotic dehiscence following preoperative irradiation with 6000 rads. Dis Colon Rectum 1984;27:176–81.
Hardy TG Jr, Pace WG, Maney JW, Katz AR, Kaganov AL. A biofragmentable ring for sutureless bowel anastomosis: an experimental study. Dis Colon Rectum 1985;28:484–90.
Unger E. Histological effects of low dose-rate gamma-irradiation. Strahlentherapie 1980;156:216–8.
Roswit B, Higgins GA Jr, Keehn RJ. Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: report of a national Veterans Administration randomized study. Cancer 1975;35:1597–1602.
Friedman P, Park WC, Afonya II, et al. Adjuvant radiation therapy in colorectal carcinoma. Am J Surg 1978;135:512–8.
Learning RH, Stearns MW, Deddish MR. Preoperative irradiation in rectal carcinoma. Radiology 1961;77:257–63.
Horwitz H. Radiotherapy in carcinoma of the rectum and anal canal. In: Turell R, ed. Diseases of the colon and anorectum. 2nd ed. Philadelphia: WB Saunders, 1969:584–98.
Roswit B, Higgins GA, Keehn RJ. Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: report of a national randomized study. Cancer 1975;35:1597–1602.
Kligerman MM. Preoperative radiation therapy in rectal cancer. Cancer 1975;36(Suppl):691–5.
Roberson SH, Heron HC, Kerman HD, Bloom TS. Is anterior resection of the rectosigmoid safe after preoperative radiation? Dis Colon Rectum 1985;28:254–9.
Pilepich MV, Munsenrider JE, Tak WK, Miller HH. Preoperative irradiation for adenocarcinoma of the rectosigmoid. Cancer 1978;42:1088–81.
Cummings BJ, Rider WD, Harwood AR, Keane TJ, Thomas GM. Radical external beam radiation therapy for adenocarcinoma of the rectum. Dis Colon Rectum 1983;26:30–6.
Morgenstern L, Sandes G, Wahlstrom E, Yadegar J, Amodeo P. Effect of preoperative irradiation on healing of low colorectal anastomoses. Am J Surg 1984;147:246–9.
Stevens KR Jr, Fletcher WS, Alen CV. Anterior resection and primary anastomosis following high dose preoperative irradiation for adenocarcinoma of the recto-sigmoid. Cancer 1978;41:2065–71.
Fletcher GH. Keynote address: the scientific basis of the present and future practice of clinical radiotherapy. Int J Radiat Oncol Biol Phys 1983;9:1073–82.
Orton CG, Ellis F. A simplification in the use of the NSD concept in practical radiotherapy. Br J Radiol 1973;46:529–37.
Overgaard M, Bentzen SM, Christensen JJ, Madsen EH. The value of the NSD formula in equation of acute and late radiation complications in normal tissue following 2 and 5 fractions per week in breast cancer patients teated with postmastectomy irradiation. Br J Radiol 1973;46:529–37.
Ellis F. Fractionation in radiotherapy. Mod Trends Radiotherapy 1967;1:34.
Hardy TG Jr, Aguilar PS, Stewart WR, et al. Initial clinical experience with a biofragmentable ring for sutureless bowel anastomosis. Dis Colon Rectum 1987;30:55–61.
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Croston, J.K., Jacobs, D.M., Kelly, P.H. et al. Experience with the biofragmentable anastomotic ring (BAR) in bowel preoperatively irradiated with 6000 rad. Dis Colon Rectum 33, 222–226 (1990). https://doi.org/10.1007/BF02134184
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DOI: https://doi.org/10.1007/BF02134184