Abstract
In order to investigate whether there is a clinical association between Fuchs' endothelial dystrophy of the cornea and atherosclerosis, the prevalence of cardiovascular disease was studied retrospectively in 27 patients with Fuchs' dystrophy and in 27 age- and sex-matched controls. The presence of cardiovascular disease was judged from a patient history of myocardial infarction, angina pectoris or heart insufficiency treated by medicaments and was found in 44% of the group with Fuchs' dystrophy and in 11% of the control group (P < 0.05). The hypothesis is advanced that there may exist a common endothelial factor of possible significance for the development of corneal endothelial dystrophy, as well as the development of atherosclerotic lesions.
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References
Bard JBL, Hay ED, Meller SM (1975) Formation of the endothelium of the avian cornea: A study of cell movement in vivo. Dev Biol 42:334–361
Becker B, Shaffer RN (1961) Diagnosis and therapy of the glaucoma. Mosby, St. Louis
Bramsen T, Stenbjerg S (1979) Fibrinolytic factors in aqueous humour and serum from patients with Fuchs' dystrophy and patients with cataract. Acta Ophthalmol (Copenh) 57:470–476
Buxton JN, Preston RW, Riechers R (1967) Tonography in cornea guttata. A preliminary report. Arch Ophthalmol 77:602–603
Cohen I (1979) Role of endothelial injury and platelets in atherogenesis. Artery 5: 237–245
Friedenwald H, Friedenwald JS (1925) Epithelial dystrophy of the cornea. Br J Ophthalmol 9:14–20
Fuchs E (1910) Dystrophia epithelialis corneae. Graefes Arch Ophthalmol 76:478–508
Hay ED, Revel J (1969) Fine structure of the developing avian cornea. S Karger, Basel New York
His (1865) cited by Altschul (1954) Endothelium. Its development, morphology, function, and pathology. MacMillan, New York
Hogan MJ, Wood I, Fine M (1974) Fuchs' endothelial dystrophy of the cornea. Am J Ophthalmol 78:363–373
Imre G, Bögi J (1979) Die verminderte Kammerwasserproduktion bei Fuchsscher Hornhautdystrophie. Klin Monatsbl Augenheilkd 174:471–474
Iwamoto T, De Voe AG (1971) Electron microscopic studies on Fuchs' combined dystrophy. Invest Ophthalmol Vis Sci 10:9–28
Kaufman HE, Capella JA, Robbins JE (1966) The human corneal endothelium. Am J Ophthalmol 61:835–841
Mishima S, Hedbys BO (1967) The permeability of the corneal epithelium and endothelium to water. Exp Eye Res 6:10–32
Moore S (1979) Endothelial injury and atherosclerosis. Exp Mol Pathol 31:182–190
Numano F, Shimamoto T (1978) Prevention and regression of atherosclerosis. In: (eds) Carlson LA et al International Conference on Atherosclerosis. Raven Press, New York, pp 631–636
Olsen T, Ehlers N, Favini E (1984) Long term results of corneal grafting in Fuchs' endothelial dystrophy. Acta Ophthalmol (Copenh) 62:445–452
Renkin EM (1978) Transport pathways through capillary endothelium. Microvasc Res 15: 123–135
Stocker FW, Irish A (1969) Fate of successful corneal grafts in Fuchs' endothelial dystrophy. Am J Ophthalmol 68:820–824
Striker GE, Harlan JM, Schwartz SM (1980) Human endothelial cells in vitro. In: Methods in cell biology, vol 21 A, Academic Press, pp 135–151
Virchow R (1856) Phlogose und Thrombose im Gefasssystem. Gesammelte Abhandlungen zur Wissenschaftlichen Medicin. Frankfurt-am-Main, Meidinger Sohn and Company, p 458
Vogt A (1929) Über keratitis bullosa bei cornea guttata. Z Augenheilkd 69: 262–264
Waring GO, Rodriques MM, Laibson PR (1978) Corneal dystrophies. II. Endothelial dystrophies. Surv Ophthalmol 23:147–168
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Olsen, T. Is there an association between Fuchs' endothelial dystrophy and cardiovascular disease?. Graefe's Arch Clin Exp Ophthalmol 221, 239–240 (1984). https://doi.org/10.1007/BF02134146
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DOI: https://doi.org/10.1007/BF02134146