Abstract
The retinal toxicity of daunomycin, a drug that effectively suppresses experimental proliferative vitreoretinopathy (PVR), was studied in the rabbit by clinical examination, electroretinography (ERG), light microscopy, and electron microscopy. Although no toxicity was observed at the therapeutically effective dose of 10 nmol per eye, the safety margin is too small to recommend this drug for therapy of proliferative vitreoretinopathy in man.
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This work was supported in part by an NIH grant EY03040 and an award from Research to Prevent Blindness, Inc., New York, New York. Presented in part at the ARVO meeting, Sarasota, Florida, USA, 1983
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Santana, M., Wiedemann, P., Kirmani, M. et al. Daunomycin in the treatment of experimental proliferative vitreoretinopathy: retinal toxicity of intravitreal daunomycin in the rabbit. Graefe's Arch Clin Exp Ophthalmol 221, 210–213 (1984). https://doi.org/10.1007/BF02134142
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DOI: https://doi.org/10.1007/BF02134142