Archives of gynecology

, Volume 239, Issue 2, pp 93–99 | Cite as

The effect of pericervical PGE2 instillation on levels of maternal serum 13,14-Dihydro-15-Keto-PGF and progesterone

  • W. Grünberger
  • J. Spona


In a prospective, randomized study 30 post-term pregnant women with low cervical scores were treated by a pericervical application of either 3 ml of 0.9% saline or 3 ml of 0.9% saline containing 1.5 mg PGE2. Twelve patients in the PGE2 group and two in the placebo group were delivered within 24 h (P < 0.001). Eight blood samples were taken from each patient and serum PGFM and progesterone levels were measured by radioimmuno-assay. In the women in whom labor started, PGFM serum levels rose progressively and progesterone levels fell consistently as the cervix dilated. After successful induction with PGE2 the variations were more marked than with labor of spontaneous onset. The PGFM-rise after PGE2 treatment must be due to stimulation of endogenous PGF production by local therapy.

Key words

Induction of labour Prostaglandin Unfavorable cervix 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Conrad JT, Ueland K (1979) The stretch modulus of human cervical tissue in spontaneous, oxytocin-induced and prostaglandin E2-induced labor. Am J Obstet Gynecol 133:11Google Scholar
  2. 2.
    Csapo AI (1977) The “sea-saw” theory of parturition. CIBA Symp 47:159Google Scholar
  3. 3.
    Fuchs AR, Husslein P, Kofler E, Grünberger W, Rasmussen A, Rehnström I (1983) Effect of cervical application of PGE2 on plasma 13,14-dihydro-15-keto-PGF and oxytocin in pregnant women at term. Br J Obstet Gynaecol 90:612Google Scholar
  4. 4.
    Gitsch E, Janisch H, Leodolter S, Schneider WHF, Spona J (1977) In: Gitsch E (Hrsg) Radioisotope in Geburtshilfe und Gynäkologie. De Gruyter, Berlin New YorkGoogle Scholar
  5. 5.
    Green K, Bydgeman M, Toppozada M, Wiquist N (1974) The role of prostaglandin F in human parturition. Endogenous plasma levels of 15-keto-13,14-dihydro-PGF during labor. Am J Obstet Gynecol 120:25Google Scholar
  6. 6.
    Grünberger W (1980) Cervical ripening before induction of labor: a new method with prosta-glandin-filled portio adapter. Clin Exp Obstet Gynecol 7:165Google Scholar
  7. 7.
    Grünberger W (1983) Geburtsinduktion und Zervixpriming mit der Prostaglandin-Kappe; eine neue Methode lokaler Prostaglandinapplikation. Probl Perinatol Med 13. Maudrich, Wien München BernGoogle Scholar
  8. 8.
    Grünberger W, Huber J, Husslein P (1984) Local application of PGE2 by means of a portio-adapter: a new method of induction of labor. Acta Obstet Gynecol Scand 63:293Google Scholar
  9. 9.
    Haning RV Jr, Kieliszek FX, Alberino SP, Speroff L (1977) A radioimmunoassay for PGFM with chromatography and internal recovery standard. Prostaglandins 13:455Google Scholar
  10. 10.
    Heap RB, Galil AKA, Harrison FA, Jenkin G, Perry JS (1977) Progesterone and oestrogen in pregnancy and parturition: comparative aspects and hierarchial control. CIBA Symp 47:127Google Scholar
  11. 11.
    Lackritz R, Tulchinsky D, Ryan KJ, Levine L (1978) Plasma prostaglandin metabolites in human labor. Am J Obstet Gynecol 131:484Google Scholar
  12. 12.
    Mackenzie IZ, Embrey MP (1979) A comparison of PGE2 und PGF vaginal gel for ripening of the cervix before induction of labor. Br J Obstet Gynaecol 86:167Google Scholar
  13. 13.
    Roux JF, Mofid M, Moss PL, Dmytrus KC (1977) Effect of elective induction of labor with prostaglandins F and E2 and oxytocin on uterine contraction and relaxation. Am J Obstet Gynecol 127:718Google Scholar
  14. 14.
    Spona J, Baumgarten K, Schmidt J, Gruber W, Gödicke HD, Grünberger W (1983) 13,14-dihydro-15-keto-PGF (PGFM) and sulproston serum levels after application of sulproston to postpartum women. Eur J Obstet Gynecol Reprod Biol 16:173Google Scholar
  15. 15.
    Stys SJ, Presser BL, Otte TE, Clark KE (1981) Effect of prostaglandin E2 on cervical compliance in pregnant ewes. Am J Obstet Gynecol 140:415Google Scholar
  16. 16.
    Szalay S, Husslein P, Grünberger W (1981) Local application of PGE2 and its influence on collagenolytic activity of cervical tissue. Sing J Obstet Gynecol 12:15Google Scholar
  17. 17.
    Wilson PD (1978) A comparison of four methods of ripening the unfavourable cervix. Br J Obstet Gynaecol 85:941Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • W. Grünberger
    • 1
  • J. Spona
    • 1
  1. 1.First Department of Obstetrics and Gynecology (Head: Prof. Dr. E. Gitsch)University of ViennaVienna

Personalised recommendations