Archives of gynecology

, Volume 239, Issue 2, pp 93–99 | Cite as

The effect of pericervical PGE2 instillation on levels of maternal serum 13,14-Dihydro-15-Keto-PGF and progesterone

  • W. Grünberger
  • J. Spona
Originals

Summary

In a prospective, randomized study 30 post-term pregnant women with low cervical scores were treated by a pericervical application of either 3 ml of 0.9% saline or 3 ml of 0.9% saline containing 1.5 mg PGE2. Twelve patients in the PGE2 group and two in the placebo group were delivered within 24 h (P < 0.001). Eight blood samples were taken from each patient and serum PGFM and progesterone levels were measured by radioimmuno-assay. In the women in whom labor started, PGFM serum levels rose progressively and progesterone levels fell consistently as the cervix dilated. After successful induction with PGE2 the variations were more marked than with labor of spontaneous onset. The PGFM-rise after PGE2 treatment must be due to stimulation of endogenous PGF production by local therapy.

Key words

Induction of labour Prostaglandin Unfavorable cervix 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • W. Grünberger
    • 1
  • J. Spona
    • 1
  1. 1.First Department of Obstetrics and Gynecology (Head: Prof. Dr. E. Gitsch)University of ViennaVienna

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