Archives of gynecology

, Volume 236, Issue 3, pp 165–172 | Cite as

Plasma angiotensin I and serum placental leucine aminopeptidase (P-LAP) in pre-eclampsia

  • S. Mizutani
  • H. Akiyama
  • O. Kurauchi
  • H. Taira
  • O. Narita
  • Y. Tomoda
Originals

Summary

A study was undertaken on serial measurements of plasma angiotensin I (A-I) and serum placental leucine aminopeptidase (P-LAP) activities in normal and pre-eclamptic pregnancy. There was the significant difference in A-I levels between normal and mild pre-eclamptic pregnancy at weeks 30, 35, and 37, between normal and severe pre-eclamptic pregnancy at week 37. There were no differences in serum P-LAP between normal and mild pre-eclamptic pregnancy up to week 33, but thereafter the levels for the mild pre-eclampsia were significantly higher than for the normal pregnancy. The P-LAP activity for the severe pre-eclampsia reached its maximum level at week 31. Around this week, the levels, for severe pre-eclampsia were significantly higher than in the normal pregnancy. After week 35, the activities decreased precipitously to week 40; the activities for severe pre-eclampsia in late pregnancy at weeks 39 and 40 were significantly lower than in normal pregnancy. The above data support the idea that P-LAP test is useful for prediction or diagnosis of pre-eclampsia.

Key words

Placental leucine aminopeptidase (p-LAP) Angiotensin I Pre-eclampsia Diagnostic value 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • S. Mizutani
    • 1
  • H. Akiyama
    • 1
  • O. Kurauchi
    • 1
  • H. Taira
    • 1
  • O. Narita
    • 1
  • Y. Tomoda
    • 1
  1. 1.Department of Obstetrics and GynecologyNagoya University School of Medicine (Director: Prof. Dr. Y. Tomoda)NagoyaJapan

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