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Lasers in Medical Science

, Volume 10, Issue 1, pp 25–30 | Cite as

Vascular contractile function following experimental excimer laser angioplasty

  • Andreas Baumbach
  • Martin Oberhoff
  • Wolfgang Kunert
  • D. Y. Xie
  • Karl K. Haase
  • Helmut Heinle
  • Karl R. Karsch
Original Articles

Abstract

The aim of this study was to determine the vasomotor response to in vivo excimer laser irradiation with regard to laser-induced tissue effects. Transfemoral excimer laser angioplasty was performed in the right carotid artery of 11 New Zealand white rabbits. In four additional rabbits (sham group), the procedure was performed without the application of laser energy. Angiography documented vessel dissection in five laser-treated animals. Perforation occurred in one animal. Rings of the treated artery and controls of the contralateral artery were investigated in a contraction chamber. The passive stress-strain relation (PSS) and the maximum contraction force (MCF) after stimulation with noradrenaline, serotonin and potassium chloride were determined. The treated vessels had a higher PSS than the control (p=0.05). The MCF was lower in the treated vessels (p<0.05). The contraction force of the sham-operated vessels was higher, although statistically not significant, compared to the laser-irradiated segments. In a subset analysis, performed to compare vessels with moderate and severe trauma, MCF was significantly reduced in vessels with severe laser-induced injury. Experimental in vivo excimer laser angioplasty in this model resulted in heterogeneous structural changes, including dissections and perforation. Post-mortem assessment of vasomotor response showed no significant difference between laser-treated and sham-operated animals. However, the contractile function of the target vessel seems to be reduced following extensive laser-induced vessel injury.

Key words

Laser angioplasty Vasoconstriction Excimer Contractile function 

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Copyright information

© W.B. Saunders Company Ltd 1995

Authors and Affiliations

  • Andreas Baumbach
    • 1
  • Martin Oberhoff
    • 1
  • Wolfgang Kunert
    • 1
  • D. Y. Xie
    • 2
  • Karl K. Haase
    • 1
  • Helmut Heinle
    • 2
  • Karl R. Karsch
    • 1
  1. 1.Division of Cardiology, Department of MedicineUniversity HospitalTübingenGermany
  2. 2.Institute of Physiology IUniversity of TübingenTübingenGermany

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