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Neuropeptide Y levels during ischemia and reperfusion in the canine infrarenal aortic revascularization model

  • Original Articles
  • Published:
Annals of Vascular Surgery

Abstract

Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two-to threefold increase in NPY levels during ischemia (initial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L,p < 0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L,p < 0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.

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Authors and Affiliations

  1. Creighton Vascular Center, Department of Surgery, Radiology, Creighton University School of Medicine, Omaha, Neb.

    John D. Edwards MD, Peter S. Dovgan MD, Jane M. Rowley MD, Patricia E. Thorpe MD & Devendra K. Agrawal PhD

  2. Creighton Vascular Center, Department of Biomedical Science, Creighton University School of Medicine, Omaha, Neb.

    John D. Edwards MD, Peter S. Dovgan MD, Jane M. Rowley MD, Thomas E. Adrian PhD & Devendra K. Agrawal PhD

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  1. John D. Edwards MD
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  2. Peter S. Dovgan MD
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  3. Jane M. Rowley MD
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  4. Patricia E. Thorpe MD
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  6. Devendra K. Agrawal PhD
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Supported by a grant from the Health Future Foundation.

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Edwards, J.D., Dovgan, P.S., Rowley, J.M. et al. Neuropeptide Y levels during ischemia and reperfusion in the canine infrarenal aortic revascularization model. Annals of Vascular Surgery 8, 350–355 (1994). https://doi.org/10.1007/BF02132996

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  • DOI: https://doi.org/10.1007/BF02132996

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