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The instability of dietary iodine supply over time in an affluent society

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Abstract

In the Bernese region, where goiter was formerly endemic, alimentary salt has been supplemented by increasing amounts of potassium iodide (KI): 5, 10, 20 mg KI/kg in 1922, 1965 and 1980 respectively. Ioduria rose from <30 μg I/g creatinine in 1920 to >100μg I/g creatinine in the 1980s. In 1992 ioduria was estimated in 55 healthy volunteers (group A and individual B) and 234 thyroid carcinoma patients after thyroidectomy: hypothyroid patients with (C) and without thyroid remnants (D) and euthyroid patients on T4** substitution (E). The arithmetic mean iodine excretion of the healthy volunteers in group A and individual B was found to be 87±40 μg I/g creatinine. This is insufficient according to the recommendations of the WHO. In all groups, the iodine excretion reached the recommended level only in some members: 24% (A, B), 19% (C), 38% (D) and 81% (E).

It was thought in the 1980s that in a formerly iodine-deficient society, iodinated salt would continue to provide an adequate supply of iodine. However, iodine intake in this affluent society has proved to be unstable. This can be attributed to modifications of eating habits, which include a reduction of total salt consumption, combined with a growing consumption of manufactured food of cosmopolitan origin, prepared using salt containing little or no iodine.

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References

  1. Jäckli, H., Ecl. geol. Helv.55 (1962), cited in: History and Iconography of Endemic Goitre and Cretinism, p. 32. Ed. F. Merke. Hans Huber Publishers, Berne-Stuttgart-Vienna 1984.

  2. Merke, F., Schweiz. med Wschr.36 (1965) 95.

    Google Scholar 

  3. Chatin, A., C.r. Acad. Sci.34 (1852) 51.

    Google Scholar 

  4. Kimball, P. O., and Marine, D., Archs intern. Med.22 (1918) 41.

    Article  CAS  Google Scholar 

  5. Marine, D., and Kimball, O. P., Archs intern. Med.25 (1920) 661.

    Article  CAS  Google Scholar 

  6. Hunziker, H., and Wyss, M. von, Schweiz. med. Wschr.52 (1922) 44.

    Google Scholar 

  7. Stiner, O., Schweiz. med. Wschr.58 (1928) 401.

    Google Scholar 

  8. Oddie, T. H., Fisher, D. A., McConahey, W. M., and Thompson, C. S., J. clin. Endocr.30 (1970) 659.

    Article  CAS  PubMed  Google Scholar 

  9. Beckers, C., Delange, F., in: Endemic goiter in endemic cretinism, p. 199. Eds J. B. Standbury and B. S. Hetzel. John Wiley and Sons, New York 1980.

    Google Scholar 

  10. Hetzel, B. S., Lancet12 (1983) 1126.

    Article  Google Scholar 

  11. Querido, A., Lancet15 (1985) 1289.

    Google Scholar 

  12. Scriba, P. C., Beckers, C., Bürgi, H., Escobar del Rey, F., Gembicki, M., Koutras, D. A., Lamberg, B. A., Langer, P., Lazarus, J. H., Querido, A., Thilly, C., and Vigneri, R., Lancet15 (1985) 1289.

    Google Scholar 

  13. Bircher, H., Der endemische Kropf und seine Beziehungen zur Taubstummheit und Cretinismus. B. Schwabe, Basel 1883.

    Google Scholar 

  14. Kocher, T., Korresp Bl. Schweizer Ärzte47 (1917) 1633.

    Google Scholar 

  15. Bayard, O., Schweiz. med Wschr.53 (1923) 703.

    Google Scholar 

  16. Hunziker, H. (ed.), Die Prophylaxe der grossen Schilddrüse. E. Bircher, Bern-Leipzig 1924.

    Google Scholar 

  17. von Fellenberg, T., Schweiz. med. Wschr.55 (1925) 53.

    Google Scholar 

  18. Dunn, J. T., J. endocr. Invest.15(Suppl 5) (1992) 5.

    Google Scholar 

  19. Horst, W., and Schneider, C., Gastroenterology97 (1962) 24.

    Article  Google Scholar 

  20. Studer, H., Kohler, H., and Bürgi, H., in: Thyroid Handbook of Physiology, vol. 3, p. 303. Eds M. A. Greer and D. H. Solomon. American Physiological Society, Washington DC3 (1974) 303.

    Google Scholar 

  21. Dunn, J. T., and van der Haar, F., A Practical Guide to the Correction of Iodine Deficiency. International Council for Control of Iodine Deficiency Disorders, WHO, UNICEF, 1990.

  22. Bayard, O., Beiträge zur Schilddrüsenfrage. Benno Schwabe, Basel 1919.

    Google Scholar 

  23. Eggenberger, H., in: Prophylaxe der grossen Schilddrüse, p. 284. Ed. H. Hunziker, E. Bircher, Bern-Leipzig 1924.

    Google Scholar 

  24. Klinger, R., Schweiz. med Wschr.52 (1922) 315.

    Google Scholar 

  25. Oswald, A., Schweiz. med Wschr.57 (1927) 731.

    Google Scholar 

  26. Steck, A., Steck, B., and König, M. P., Schweiz. med. Wschr.102 (1972) 829.

    CAS  PubMed  Google Scholar 

  27. Eberhard, H., Eigenmann, F., Schärer, K., and Bürgi, H., Schweiz. med. Wschr.113 (1983) 24.

    CAS  PubMed  Google Scholar 

  28. Mordasini, C., Abetel, G., Lauterburg, H., Ludi, P., Perrenoud, J. P., Schmid, H., and Studer, H., Schweiz. med. Wschr.114 (1984) 1924.

    CAS  PubMed  Google Scholar 

  29. Bürgi, H., Supersaxo, Z., and Selz, B., Acta endocr.123 (1990) 577.

    PubMed  Google Scholar 

  30. Supersaxo, Z., Selz, B., Hasler, P., Wespi, H. J., Abelin, T., and Bürgi, H., Schweiz. med. Wschr.121 (1991) 317.

    CAS  PubMed  Google Scholar 

  31. Jaffé, M., Hoppe-Seyler's Z. physiol Chem.10 (1886) 399.

    Google Scholar 

  32. Sandell, E. B., and Kolthoff, J. M., Acta microbiol.1 (1937) 9.

    Article  CAS  Google Scholar 

  33. Lauber, K., Analyt. Chem.47 (1975) 769.

    Article  CAS  Google Scholar 

  34. Schmid, M., Schulthess, H., Bürgi, H., and Studer, H., Schweiz. med Wschr.110 (1980) 1290.

    CAS  PubMed  Google Scholar 

  35. Bürgi, H., Supersaxo, Z., and Dürig, P., in: Iodine Deficiency in Europe, p. 367. Eds F. Delange, J. T. Dunn and D. Glinoer. Plenum Press, New York-London 1993.

    Chapter  Google Scholar 

  36. Bourdoux, P., Delange, F., Filetti, S., Thilly, C., Ermans, A. M., in: Thyroid Disorders Associated with Iodine Deficiency and Excess, p. 145. Eds R. Hall and J. Köbberling. Raven Press, New York 1985.

    Google Scholar 

  37. Vought, R. L., London, W. T., Lutwak, L., and Dublin, T. D., J. clin. Endocr.23 (1963) 1218.

    Article  CAS  PubMed  Google Scholar 

  38. Jolin, T., and Escobar del Rey, F., J. clin. Endocr. Metab.25 (1965) 540.

    Article  CAS  PubMed  Google Scholar 

  39. Kocher, T., in: Vorkommen und Vertheilung des Kropfes im Kanton Bern. Ein Beitrag zur Kenntniss der Ursachen der Kropfbildung. Ed. K. Wyss, Bern 1889.

  40. Dieterle, T., Hirschfeld, L., and Klinger, R., Acta hyg.81 (1913) 128.

    Google Scholar 

  41. Riccabona, G., Acta endocrin.55 (1967) 545.

    CAS  Google Scholar 

  42. Sieber, R., in: Dritter Schweizerischer Ernährungsbericht, p. 20. Ed. Bundesamt für Gesundheitswesen. EDMZ, Bern 1991.

    Google Scholar 

  43. Hohmann-Beck, B., in: Dritter Schweizerischer Ernährungsbericht, p. 280. Ed. Bundesamt für Gesundheitswesen. EDMZ, Bern 1991.

    Google Scholar 

  44. Morgan, T., Gillies, A., Morgan, G., Adam, W., Wilson, M., and Carney, S., Lancet (1978) 227.

  45. Finn, R., McConnochie, K., Box, D. E. O., Fennerty, A. G., and Green, R., Lancet (1981) 1097.

  46. Shekelle, R. B., Shyrock, A. M., Paul, O., Lepper, M., Stamler, J., Liu, S., and Raynor, W. J., N. Engl. J. Med.304 (1981) 65.

    Article  CAS  PubMed  Google Scholar 

  47. WHO Expert Committee. Prevention of Coronary Heart Disease. Technical Report Series 678. Copenhagen 1982.

  48. Arab, L., Schelleberg, B., and Schlierf, G., Ann. Nutr. Metab.26(Suppl. 1) (1982) 1.

    PubMed  Google Scholar 

  49. Watt, G., Foy, C., and Tudor-Hart, J., Lancet (1983) 1245.

  50. MacGregor, G., Markandu, N., Best, F. E., Elder, D. M., Cam, J. M., Sagnella, G. A., and Squires, M., Lancet (1982) 351.

  51. WHO. Comprehensive Cardiovascular Community Control Programmes in Europe. WHO Regional Office for Europe, Copenhagen 1988.

    Google Scholar 

  52. Gutzwiler, F., Rickenbach, M., Bopp, M., La Vecchia, C., and Levi, F., in: Dritter Schweizerischer Ernährungsbericht, p. 423. Ed. Bundesamt für Gesundheitswesen. EDMZ, Bern 1991.

    Google Scholar 

  53. Gugelmann, E., Die Lebensmittel der Migros. Brückenbauer, 1989. Cited in ref. 42.

  54. Moses, C., Sodium in medicine and health. Salt Institute Baltimore, Maryland, USA 1980.

    Google Scholar 

  55. The Nutrition Foundation. Biological and Behavioral Aspects of Salt Intake. Academic Press Inc, Washington 1980.

    Google Scholar 

  56. Spinnler, K., and Studer, H., in: Zweiter schweizerischer Ernährungsbericht. Bundesamt für Gesundheitswesen, p. 299. Eds H. Aebi, M. Blumenthal, M. Bohren-Hoerni, G. Brubacher, U. Frey, H.-R. Müller, G. Ritzel and M. Stransky. hans Huber Verlag, Bern 1984.

    Google Scholar 

  57. Kieffer, F., in: Zweiter schweizerischer Ernährungsbericht. Bundesamt für Gesundheitswesen, p. 81. Eds H. Aebi M. Blumenthal, M. Bohren-Hoerni, G. Brubacher, U. Frey, H.-R. Müller, G. Ritzel and M. Stransky. Hans Huber Verlag, Bern 1984.

    Google Scholar 

  58. Stransky, M., Scheffeldt, P., Schönhauser, R., and Blumenthal, A., Mitt. Geb. Lebensmittelunters. u. Hyg.78 (1987) 44.

    Google Scholar 

  59. Wyttenbach, A., Bajo, S., Tobler, L., and Zimmerli, B., in: Trace Element-Analytical Chemistry in Medicine and Biology, vol. 4, p. 169. Ed. P. P. S. Brätter. W. de Gruyter, Berlin-New York 1987.

    Google Scholar 

  60. Schlierf, G., Arab, L., and Schellenberg, B., Aktuelle Ernährungsmedizin.3 (1981) 123.

    Google Scholar 

  61. Weber, P., Manz, F., Kersting, M., and Schöch, G., Dt. med. Wschr.111 (1986) 1916.

    Article  CAS  Google Scholar 

  62. James, W. P. T., and Ralph, A., Lancet (1987) 426.

  63. Oddie, T. H., Pirnique, G. F., Fisher, D. A., and Maede, J. H., J. clin. Endocr.28 (1968) 761.

    Article  CAS  PubMed  Google Scholar 

  64. Sanchez-Castillo, C. P., Clin. Sci.72 (1972) 81.

    Article  Google Scholar 

  65. Vought, R. L., London, W. T., Brown, F. A., Eckloff, J. C., and Murphy, R. S., Am. J. clin. Nutr.15 (1964) 124.

    Article  CAS  PubMed  Google Scholar 

  66. Wickham, C., Barry, A., and Kevany, J., Lancet (1983) 1219.

  67. Lamberg, B. A., in: Thyroid Disorders Associated with Iodine Deficiency and Excess, vol. 22, p. 81. Eds R. Hall and J. Köbberling. Serono Symp. Publ. Raven Press, New York 1985.

    Google Scholar 

  68. Hintze, G., Köbberling, J., Emrich, D., Wasielewski, T., and Thal, T., Acta endocrin.108(Suppl. 267) (1985) 80.

    Google Scholar 

  69. Gutekunst, R., Smolarek, H., Hasenpusch, U., Stubbe, P., Friedrich, H. J., Wood, W. G., and Scriba, P. C., Acta endocrin.112 (1986) 494.

    CAS  Google Scholar 

  70. Emrich, D., in: Schilddrüse, 1985, p. 331. Ed. P. Pfannenstiel, D. Emrich, R. Weinheimer. Thieme Verlag, Stuttgart 1986.

    Google Scholar 

  71. Delange, F., and Bürgi, H., WHO Bulletin67 (1989) 317.

    CAS  Google Scholar 

  72. Bull, N. L., and Buss, D. H., Proc. Nutr. Soc.39 (1980) A30.

    Google Scholar 

  73. Sieber, R., Collomb, M., and Steiger, G., Mitt. Geb. Lebensmittelunters. u. Hyg.78 (1987) 106.

    CAS  Google Scholar 

  74. Sieber, R., Lebensmittel Technologie22 (1989) 66.

    Google Scholar 

  75. Hess, W., Natürlich7 (1987) 46.

    Google Scholar 

  76. Sieber, R., and Rüegg, M., Lebensmittel Technologie21 (1988) 9 and 34.

    Google Scholar 

  77. Erard, M., and Sieber, R., in: Dritter Schweizerischer Ernährungsbericht, p. 31. Ed. Bundesamt für Gesundheitswesen. EDMZ, Bern 1991.

    Google Scholar 

  78. Blumenthal, A., Scheffeldt, P., and Schönhauser, R., Mit. Geb. Lebensmittelunters. u. Hyg.74 (1983) 80.

    CAS  Google Scholar 

  79. Bürgi, H., Baumgartner, H., and Steiger, G., Schweiz. med. Wschr.112 (1982) 2.

    PubMed  Google Scholar 

  80. Hemken, R. W., J. Anim. Sci.48 (1979) 981.

    Article  CAS  PubMed  Google Scholar 

  81. International Dairy Federation. Iodine in milk. Production, Hygiene and Quality of Milk. Annual Session in Bristol 1980.

  82. Merke, F., Schweiz. med. Wschr.98 (1968) 1535.

    CAS  PubMed  Google Scholar 

  83. Geiser, J., Bürgi, H., Grob, P. J., and Studer, H., Schweiz. med. Wschr.108 (1978) 1152.

    CAS  PubMed  Google Scholar 

  84. Gerber, D., Schweiz. med. Wschr.110 (1980) 2010.

    CAS  PubMed  Google Scholar 

  85. Bohnhoff, Z., Schweiz. med. Wschr.118 (1988) 244.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, University of Berne, CH-3010, Berne, Switzerland

    C. Als, D. Lüscher & H. Rösler

  2. Department of Clinical Chemistry, Inselspital, University of Berne, CH-3010, Berne, Switzerland

    K. Lauber & L. Brander

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  1. C. Als
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Als, C., Lauber, K., Brander, L. et al. The instability of dietary iodine supply over time in an affluent society. Experientia 51, 623–633 (1995). https://doi.org/10.1007/BF02128756

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