Agents and Actions

, Volume 26, Issue 1–2, pp 87–89 | Cite as

Evidence indicating that leukotrienes C4, D4 and E4 are major mediators of contraction induced by anti-IgE in human bronchi

  • T. Björck
  • S. -E. Dahlén
Mediators of Hypersensitivity Reactions

Keywords

Major Mediator Human Bronchus 

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References

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    S.-E. Dahlén, G. Hansson, P. Hedqvist, T. Björck, E. Granström and B. Dahlén,Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C 4,D 4 and E 4. Proc. Natl. Acad. Sci. USA80, 1712–1718 (1983).PubMedGoogle Scholar
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    A. Sydbom, M. Kumlin and S.-E. Dahlén,Stimulus-dependence and time-course of histamine and leukotriene release from chopped and dispersed human lung tissue. Agents and Actions20, 198–201 (1987).PubMedGoogle Scholar
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    T. R. Jones, Y. Guindon, R. Young, E. Champion, L. Charette, D. Denis, D. Ethier, R. Hamel, A. W. Ford-Hutchinson, R. Fortin, G. Letts, P. Masson, C. McFarlane, H. Piechuta, J. Rokach, C. Yoakim, R. N. De Haven, A. Maycock and S. S. Pong,L-648,051; sodium 4-[3-(4-acetyl-3-hydroxy-2-prophylphenoxy)-propylsulfonyl]-γ-oxo-benzenebutanoate: a leukotriene D 4 receptor antagonist. Can. J. Physiol. Pharmacol.64, 1535–1542 (1986).PubMedGoogle Scholar
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    S.-E. Dahlén, P. Hedqvist, S. Hammarström and B. Samuelsson,Leukotrienes are potent constrictors of human bronchi. Nature288, 484–486 (1980).PubMedGoogle Scholar
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    N. C. Barnes, J. M. Evans, J. T. Zakrezewski, P. J. Piper and J. F. Costello,L-648,051 a leukotriene D 4 antagonist is active by the inhaled route in man. Abstract at the Tenth International Congress of Pharmacology (IUPHAR)O 34 (1987).Google Scholar

Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • T. Björck
    • 1
  • S. -E. Dahlén
    • 1
  1. 1.Department of Physiology, and Institute of Environmental MedicineKarolinska InstitutetStockholmSweden

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