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Agents and Actions

, Volume 26, Issue 1–2, pp 87–89 | Cite as

Evidence indicating that leukotrienes C4, D4 and E4 are major mediators of contraction induced by anti-IgE in human bronchi

  • T. Björck
  • S. -E. Dahlén
Mediators of Hypersensitivity Reactions

Keywords

Major Mediator Human Bronchus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    S.-E. Dahlén, G. Hansson, P. Hedqvist, T. Björck, E. Granström and B. Dahlén,Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C 4,D 4 and E 4. Proc. Natl. Acad. Sci. USA80, 1712–1718 (1983).PubMedGoogle Scholar
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    A. Sydbom, M. Kumlin and S.-E. Dahlén,Stimulus-dependence and time-course of histamine and leukotriene release from chopped and dispersed human lung tissue. Agents and Actions20, 198–201 (1987).PubMedGoogle Scholar
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    T. R. Jones, Y. Guindon, R. Young, E. Champion, L. Charette, D. Denis, D. Ethier, R. Hamel, A. W. Ford-Hutchinson, R. Fortin, G. Letts, P. Masson, C. McFarlane, H. Piechuta, J. Rokach, C. Yoakim, R. N. De Haven, A. Maycock and S. S. Pong,L-648,051; sodium 4-[3-(4-acetyl-3-hydroxy-2-prophylphenoxy)-propylsulfonyl]-γ-oxo-benzenebutanoate: a leukotriene D 4 receptor antagonist. Can. J. Physiol. Pharmacol.64, 1535–1542 (1986).PubMedGoogle Scholar
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    S.-E. Dahlén, P. Hedqvist, S. Hammarström and B. Samuelsson,Leukotrienes are potent constrictors of human bronchi. Nature288, 484–486 (1980).PubMedGoogle Scholar
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    N. C. Barnes, J. M. Evans, J. T. Zakrezewski, P. J. Piper and J. F. Costello,L-648,051 a leukotriene D 4 antagonist is active by the inhaled route in man. Abstract at the Tenth International Congress of Pharmacology (IUPHAR)O 34 (1987).Google Scholar

Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • T. Björck
    • 1
  • S. -E. Dahlén
    • 1
  1. 1.Department of Physiology, and Institute of Environmental MedicineKarolinska InstitutetStockholmSweden

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