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, Volume 26, Issue 1–2, pp 45–47 | Cite as

Inflammatory mediators andβ-adrenoceptor function

  • J. A. M. Raaijmakers
  • C. Beneker
  • E. C. G. van Geffen
  • T. M. H. Meisters
  • P. Pover
Mediators of Hypersensitivity Reactions

Abstract

In this study the,in vitro, influence of arachidonic acid metabolites on humanβ-adrenoceptors was investigated. Incubation of normal human pulmonary membranes with PAF, LTB4 and LTC4 affected pulmonaryβ-adrenoceptor properties, as was shown in radioligand binding studies. The same mediators were able to induce a decreased lymphocyte cAMP synthesis. It is concluded thatβ-adrenoceptor deficiencies, that can be demonstrated in peripheral lung tissue of COLD patients, may result from pathological processes such as inflammation.

Keywords

Arachidonic Acid Lung Tissue Inflammatory Mediator Pathological Process Binding Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • J. A. M. Raaijmakers
    • 1
  • C. Beneker
    • 1
  • E. C. G. van Geffen
    • 1
  • T. M. H. Meisters
    • 1
  • P. Pover
    • 1
  1. 1.Department of Pulmonary DiseaseState University HospitalUtrechtThe Netherlands

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