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Postsynaptic long-term potentiation follows coupling of dendritic glutamate application and synaptic activation

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Summary

Dendritic depolarization, which seems to be involved in the induction of long-term potentiation (LTP), was elicited by localized glutamate application. When paired to low frequency synaptic activation in the same area, the subsequent changes had features in common with LTP, expressed as an increased probability of firing and shorter spike latency. The EPSP was not significantly increased.

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  1. Acknowledgments. This work was supported by the Norwegian Research Council for Science and the Humanities, by a NATO Science Fellowship (J.-C.L.) from the Natural Sciences and Engineering Research Council of Canada and by a Fellowship (G.-Y.H.) from the Norwegian Development Agency — NORAD.

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Authors and Affiliations

  1. Institute of Neurophysiology, University of Oslo, N-0162, Oslo 1, Norway

    Ø. Hvalby, J. -C. Lacaille, G. -Y. Hu & P. Andersen

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  1. Ø. Hvalby
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  2. J. -C. Lacaille
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  3. G. -Y. Hu
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  4. P. Andersen
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Hvalby, Ø., Lacaille, J.C., Hu, G.Y. et al. Postsynaptic long-term potentiation follows coupling of dendritic glutamate application and synaptic activation. Experientia 43, 599–601 (1987). https://doi.org/10.1007/BF02126343

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  • DOI: https://doi.org/10.1007/BF02126343

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