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Evidence of a direct action of triiodothyronine (T3) on the cell membrane of GH3 cells: an electrophysiological approach

Experientia volume 43, pages 596–598 (1987)Cite this article

Summary

Electrophysiological experiments demonstrate that triiodothyronine (T3) exerts a direct effect on the membrane of a strain of cultured rat pituitary tumor cells, GH3/B6. These cells respond to pressure application of T3 (2–5 nl, concentration 1·10−10 M) with an increase in the membrane resistance (Rm) and a hyperpolarization. Spontaneously firing cells become silent.

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Affiliations

  1. Biologisch Centrum Gebouw 11, University of Amsterdam, Dept. of Zoology, Kruislaan 320, NL-1098 SM, Amsterdam, (The Netherlands)

    J. S. du Pont & J. -M. Israel

  2. I.N.S.E.R.M. U. 176, Neurobiologie des compartements, Domaine de Carreire, Rue Camille Saint-Saens, F-33076, Bordeaux Cedex, (France)

    J. S. du Pont & J. -M. Israel

Authors
  1. J. S. du Pont
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  2. J. -M. Israel
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du Pont, J.S., Israel, J.M. Evidence of a direct action of triiodothyronine (T3) on the cell membrane of GH3 cells: an electrophysiological approach. Experientia 43, 596–598 (1987). https://doi.org/10.1007/BF02126342

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  • DOI: https://doi.org/10.1007/BF02126342

Key words

  • Triiodothyronine
  • GH3 cells
  • membrane potential
  • membrane resistance
  • action potentials