Skip to main content
SpringerLink
Log in

Evidence of a direct action of triiodothyronine (T3) on the cell membrane of GH3 cells: an electrophysiological approach

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Electrophysiological experiments demonstrate that triiodothyronine (T3) exerts a direct effect on the membrane of a strain of cultured rat pituitary tumor cells, GH3/B6. These cells respond to pressure application of T3 (2–5 nl, concentration 1·10−10 M) with an increase in the membrane resistance (Rm) and a hyperpolarization. Spontaneously firing cells become silent.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Kidokoro, Y., Nature258 (1975) 741.

    Article  CAS  PubMed  Google Scholar 

  2. Taraskevich, P.S., and Douglas, W.W., Neuroscience5 (1980) 421.

    Article  CAS  PubMed  Google Scholar 

  3. Ozawa, S., and Kimura, N., Proc. natn. Acad. Sci. USA76 (1979) 6017.

    Article  CAS  Google Scholar 

  4. Dufy, B., Vincent, J.-D., Fleury, H., Du Pasquier, P., Gourdji, D., and Tixier-Vidal, A., Science204 (1979) 509.

    Article  CAS  PubMed  Google Scholar 

  5. Maruyama, T., Shiino, M., and Rennels, E.G., Neuroendocrinology32 (1981) 28.

    Article  CAS  PubMed  Google Scholar 

  6. Sterling, K., New Engl. J. Med.300 (1975) 117.

    Article  Google Scholar 

  7. Sterling, K., New Engl. J. Med.300 (1975) 173.

    Article  Google Scholar 

  8. Garcia, M.D., Escobar del Rey, F., and Morreale de Escobar, G., Endocrinology98 (1976) 203.

    Article  CAS  PubMed  Google Scholar 

  9. Hervas, F., Morreale de Escobar, G., and Escobar del Rey, F., Endocrinology97 (1975) 91.

    Article  CAS  PubMed  Google Scholar 

  10. Horiuchi, R., Cheng, S.-Y., Willingham, M., and Pastan, I., J. biol. Chem.257 (1982) 3139.

    Article  CAS  PubMed  Google Scholar 

  11. Horiuchi, R., Johnson, M.L., Willingham, M., Pastan, I., and Cheng, S.-Y., Proc. natn. Acad. Sci. USA79 (1982) 5527.

    Article  CAS  Google Scholar 

  12. Dufy, B., Vincent, J-D., Fleury, H., Du Pasquier, P., Gourdji, D., and Tixier-Vidal, A., Nature282 (1979) 855.

    Article  CAS  PubMed  Google Scholar 

  13. Ozawa, S., Biomed. Res.1, suppl. (1980) 140.

    CAS  Google Scholar 

  14. Samuels, H.H., Tsai, J.R., and Cintron, R., Science181 (1973) 1253.

    Article  CAS  PubMed  Google Scholar 

  15. Jørgensen, E.C., Thyroid hormones, in: Hormonal Proteins and Peptides, vol. 6. Ed. C.H. Li, Academic Press, New York 1978.

    Google Scholar 

  16. Campbell, R.C. Statistics for Biologist. Cambridge University Press, 1974.

  17. Trifaro, J.M., A. Rev. Pharmac. Toxic.17 (1977) 27.

    Article  CAS  Google Scholar 

  18. Williams, J.A., J. theor. Biol.28 (1970) 287.

    Article  CAS  PubMed  Google Scholar 

  19. Tixier-Vidal, A., and Gourdij, D., Physiol. Rev.61 (1981) 974.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biologisch Centrum Gebouw 11, University of Amsterdam, Dept. of Zoology, Kruislaan 320, NL-1098 SM, Amsterdam, The Netherlands

    J. S. du Pont & J. -M. Israel

  2. I.N.S.E.R.M. U. 176, Neurobiologie des compartements, Domaine de Carreire, Rue Camille Saint-Saens, F-33076, Bordeaux Cedex, France

    J. S. du Pont & J. -M. Israel

Authors
  1. J. S. du Pont
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. -M. Israel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

du Pont, J.S., Israel, J.M. Evidence of a direct action of triiodothyronine (T3) on the cell membrane of GH3 cells: an electrophysiological approach. Experientia 43, 596–598 (1987). https://doi.org/10.1007/BF02126342

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02126342

Key words

Search

Navigation