Wechselwirkungen zwischen Myxoviren und Zelloberflächen

III. Neuraminidase der Myxoviren
  • Rudolf Drzeniek
Article

Zusammenfassung

Neuraminidasen der Myxoviren sind virusgekodete Enzyme, die sich in ihrer Antigenität und Substratspezifität voneinander unterscheiden. Sie lassen sich durch Polyanionen in Mikrogramm-Mengen hemmen. Diese Hemmung ist pH-abhängig und reversibel nach Zugabe von Polykationen.

Mit Butanol und Pronase wurde Neuraminidase vom Viruspartikel abgespalten und gereinigt. Die gereinigten Präparationen besitzen die gleichen enzymkinetischen Eigenschaften wie die virusgebundenen Neuraminidasen. Die Sedimentationskonstante der vom Virus losgelösten Neuraminidase liegt bei 9–10 S. Antiseren, die durch Immunisieren von Kaninchen mit gereinigter Neuraminidase erhalten wurden, inhibieren nur das Enzym des homologen Virusstammes. Sie hemmen nicht die durch Influenzaviren bedingte Agglutination von Erythrocyten.

Interactions between myxoviruses and cell surfaces

III. Neuraminidase of Myxoviruses

Summary

Neuraminidases of myxoviruses are coded by the viral genome because they differ in their antigenicity and substrate specifity. They are inhibited by polyanionic substances at the microgram level. The inhibition is pH dependent and may be reversed by addition of polycationic substances.

The enzyme may be released from the virus by treating the particle with n-butanol and pronase. Purified preparations have the same kinetic properties as the virus-bound enzymes. Their sedimentation coefficients are 9–10 S. Antisera obtained by immunization of rabbits with purified neuraminidase inhibit specifically only the enzyme of the homologous virus strain. They do not inhibit, however, the hemagglutination between influenza viruses and red blood cells.

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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • Rudolf Drzeniek
    • 1
  1. 1.Institut für Virologie der Justus Liebig-UniversitätGießen

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