Skip to main content

Advertisement

SpringerLink
Log in

Occurrence of lymphomas and lupus erythematosus-like syndrome in the course of experimental Candida albicans infection in mice

  • Published:
Mycopathologia et mycologia applicata Aims and scope Submit manuscript

Abstract

Occurrence of four lymphomas was seen following injection of 1.4×103 Candida albicans cells to the spleen of eighty non - inbred albine mice. These neoplastic changes occurred in three to seven months of the duration of the experiment. Extensive invasion of the subcutaneous tissue by the tumor was found in one animal. Two of the animals with lymphoma also had changes in the kidneys compatible with lupus erythematosus and presence of LE cells in the blood. In other animals most frequent and extensive pathological changes were found in the kidneys and in order of frequency were as follows: thickening of the basement membrane, fibrinoid degeneration, presence of hematoxylin bodies, wireloop formation. In total, the presence of positive LE cells in blood was found in seven instances and suggestive LE cells was observed in eight animals. Finding of perisplenitis, exudative pleuritis and pericarditis gave additional support to the resemblance of observed pathological changes with human lupus erythematosus. The fact that occurrence of lymphomas and lupus erythematosus together has been reported in humans provides additional interest to the results reported.

Results presented here and previously suggest that there may be more extensive interrelationship among variety of pathological changes observed than is accepted until now. Better understanding of host — parasite relationship ofCandida albicans, and possible other fungi, could advance out knowledge of pathogenesis of these diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Alarcon-Segovia, D., Galbraith, R. F., Maldonado, J. E. &Howard, F. M., Jr. (1963) Systemic lupus erythematosus following thymectomy for myasthenia gravis. Report of two cases.Lancet 2:662–665.

    Google Scholar 

  • Bailiff, R. N. (1956) Graduated loading of the reticulo-endothelium and growth rate ofErlith mouse ascites tumor.Cancer Research 16:479–483.

    PubMed  Google Scholar 

  • Banks, B. M. (1941) Is there a common denominator in scleroderma, dermatomyositis, dissiminated lupus erythematosus,Libman-Sacks syndrome and polyarteritis nodosa?New England J. of Medicine 225:433–444.

    Google Scholar 

  • Barber, H. W. (1915) A case of acute lupus erythematosus.Brit. J. Derm. 27:365–371.

    Google Scholar 

  • Blackburn, C. R. B. (1954) The management of chronic hypoparathyroid tetany.Med. J. of Australia 1:928–935.

    Google Scholar 

  • Boeck, C. (1898) Discussion on the etiology of lupus erythematosus.Brit J. Derm. 10:371–376.

    Google Scholar 

  • Brigden, W., Bywaters, E. G., Lessof, M. H. &Ross, I. P. (1960) The heart in systemic lupus erythematosus.Brit. Heart J. 22:1–16.

    PubMed  Google Scholar 

  • Cammarata, R. J., Jensen, W. N. &Rodnan, G. P. (1961) Association of systemic rheumatic disease and malignant lymphoma.Clin. Res. 9:329–334.

    Google Scholar 

  • Doniach, D. &Roitt, I. M. (1962) Auto-antibodies in disease.Ann. Rev. Med. 13:218–340.

    Google Scholar 

  • Dubois, E. L. (1952) Acquired hemolytic anemia as presenting syndrome of lupus erythematosus disseminatus.Amer. J. Med. 12:197–204.

    PubMed  Google Scholar 

  • Dubois, E. L. (1953) Effect of LE cell test on clinical picture of systemic lupus erythematosus.Ann. Intern. Med. 38:1265–1294.

    PubMed  Google Scholar 

  • Dubois, E. L. (1962) The spectrum between rheumatoid arthritis and lupus erythematosus. abst.Arthritis Rheum. 5:293.

    Google Scholar 

  • Dubois, E. L. Lupus Erythematosus. (1966) McGraw-Hill Co., New York.

    Google Scholar 

  • Dubois, E. L. &Freeman, V. (1957) Comparative evaluation of the sensitivity of the LE cell test performed simultaneously by different methods.Blood 12:657–670.

    PubMed  Google Scholar 

  • Dubois, E. L. &Tuffanelli, D. L. (1964) Clinical manifestations of systemic lupus erythematosus.JAMA 190:104–111.

    PubMed  Google Scholar 

  • Dustan, H. P., Taylor, R. D., Corcoran, A. C. &Page, I. H. (1954) Rheumatic and febrile syndrome during prolonged hydralazine treatment.JAMA 154:23–29.

    Google Scholar 

  • Echinique, L., Garcia-Vidal, W. &Sosa de Caruso, N. (1958) Moniliasis de los lechones aCandida albicans.An. Fac. Vet. Urug. 8:77–87.

    Google Scholar 

  • Galbraith, R. F., Summerskill, W. H. J. &Murray, J. (1964) Systemic lupus erythematosus, cirrhosis, and ulcerative colitis after thymectomy for myasthenia gravis.The New England J. of Medicine 270:229–232.

    Google Scholar 

  • Glaser, G. H. (1952) Lesions of the central nervous system in disseminated lupus erythematosus.Arch. Neur. & Psychiat. 67:745–751.

    Google Scholar 

  • Goldin, H. &Robbins, W. C. (1963) A patient with myasthenia gravis, thymoma and lupus nephritis.American Rheumatism Association 6:272–273.

    Google Scholar 

  • Harvey, A. M., Shulman, L. E., Tumulty, P. A., Conley, C. L. &Schoenrich, E. H. (1954) Systemic lupus erythematosus; a review of the literature and clinical analysis of 138 cases.Medicine 33:291–437.

    PubMed  Google Scholar 

  • Helyer, B. J. &Howie, J. B. (1961) Positive lupus erythematosus tests in a crossbred strain of mice NZB/BI-NZY/BI.Proc. Univ. Otago (New Zealand) Med. School 39:3–4.

    Google Scholar 

  • Helyer, B. J. &Howie, J. B. (1963) Spontaneous auto-immune disease in NZB/BL mice.Brit. J. Haemat. 9:119–131.

    PubMed  Google Scholar 

  • Howie, J. B. &Helyer, B. J. (1965) Autoimmune disease in mice.Ann. N. Y. Acad. Sci. 124:167–177.

    PubMed  Google Scholar 

  • Howqua, J. &Mackay, I. R. (1963) LE cells in lymphoma.Blood 22:191–198.

    PubMed  Google Scholar 

  • Jaffe, R. H., (1931) The reticuloendothelial system in immunity.Physiol. Rev. 11:277–327.

    Google Scholar 

  • Kabir, D. I. &Malkinson, F. D. (1969) Lupus erythematosus and calcinosis cutis.Arch. Derm. 100:17–22.

    PubMed  Google Scholar 

  • Keats, T. E. (1961) The collagen diseases: a demonstration of the nonspecifity of their extrapulmonary manifestations.Amer. J. Roentgen. 86:937–943.

    Google Scholar 

  • Klemperer, P., Pollack, A. D. &Baehr, G. (1941) Pathology of disseminated lupus erythematosus.Arch. Path. 32:569–631.

    Google Scholar 

  • Klinge, F. (1933) Der rheumatismus.Ergeb. Allg. Pathol. 27:1–39.

    Google Scholar 

  • Lansbury, J. (1953) Collagen disease complicating malignancy.Ann. Rheum. Dis. 12:301-.

    PubMed  Google Scholar 

  • Larson, D. L. (1961)Systemic Lupus Erythematosus. Little Brown & Co., Boston.

    Google Scholar 

  • Larsson, O. (1963) Thymoma and systemic lupus erythematosus in the same patientLancet 2:665–666.

    Google Scholar 

  • Libman, E. &Sacks, B. (1923) A higherto undescribed form of valvular and mural endocarditis.Trans. Assoc. Amer. Phys. 38:46-.

    Google Scholar 

  • Mackay, I. R. (1966) Autoimmune aspects of systemic lupus erythematosus and the forbidden clone hypothesis. InDubois, E. L., ed., Lupus Erythematosus, McGraw-Hill Co., 1966. pp. 85–92.

  • Mäkelä, T. E., Ruosteenoja, R., Wager, O., Wallgren, G. R. &Jokinen, E. J. (1964) Myasthenia gravis and systemic lupus erythematosus.Acta Medica Scandinavica 175:777–780.

    PubMed  Google Scholar 

  • Mankowski, Z. T. (1957) The experimental pathogenicity of various species ofCandida in Swiss mice.Transactions of the N. Y. Academy of Sciences 19:548–570.

    Google Scholar 

  • Mankowski, Z. T. (1962) Occurence of calcinosis in the course of experimental fungus infections.Sabouraudia 1:234–236.

    PubMed  Google Scholar 

  • Mankowski, Z. T. (1962) The pathological activity of metabolic products ofCandida albicans on newborn mice.Mycopath. Mycol. Appl. 17:165–175.

    Google Scholar 

  • Mankowski, Z. T. (1963) Occurrence of malignancy, collagen diseases and myasthenia gravis in the course of experimental infections withCandida albicans.Mycopath. Mycol. Appl. 19:1–20.

    Google Scholar 

  • Mankowski, Z. T. (1964) The occurrence of liver portal cirrhosis and atrophy of the islet cells of the pancreas in the course of experimentalCandida albicans infection.Mycopath. Mycol. Appl. 22:271–284.

    Google Scholar 

  • Mankowski, Z. T. (1966) Blood changes and fertility derangements following the injection ofCandida albicans into the spleen of the experimental animals (occurence of hypersplenism).Mycopath. Mycol. Appl. 30:59–71.

    Google Scholar 

  • Mankowski, Z. T. (1968) Production of glycoprotein byCandida, albicans in a synthetic medium and its influence on the growth of newborn mice.Mycopath. Mycol. 34: 113–118.

    Google Scholar 

  • Mankowski Z. T. (1968) Seizure induction by pentylenetetrazol in animals experimentally infected withCandida albicans.Mycopathol. Mycol. Appl. 34:108–112.

    PubMed  Google Scholar 

  • Mankowski, Z. T. (1971) Seizure induction by pentylenetetrazol in rodents receivingCandida albicans glycoprotein orally.Mycopathol. Mycol. Appl. 45:131–136

    PubMed  Google Scholar 

  • Mankowski, Z. T. (1971) Influence ofCandida albicans glycoprotein on 3-methylcholanthrene induced malignancy in newborn rodents.Mycopath. Mycol. Appl. 44:95–100.

    Google Scholar 

  • Mankowski, Z. T. (1971) Occurence of atypical lymphocytes following intravenous injection ofCandida albicans in mice.Mycopath. Mycol. Appl. 45:243–251.

    Google Scholar 

  • Massachusetts General Hospital Case Records (1954) Case No. 40361.New England J. Med. 251:442–448.

    Google Scholar 

  • Mellors, R. C. &Huang, C. Y. (1966) Immunopathology of NZB/bl mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy.J. Exp. Med. 124:1031–1038.

    PubMed  Google Scholar 

  • Mellors, R. C. &Huang, C. Y. (1967) Immunopathology of NZB/bl mice. VI. Virus separable from spleen and pathogenic for Swiss mice.J. Exp. Med. 126:53–61.

    PubMed  Google Scholar 

  • Moolten, S. E. &Clark, E. (1952) The red blood cell as a vehicle of virus transport I. Isolation and identification of blood-borne viruses.Trans. N. Y. Acad. Sci. 14:232–235.

    PubMed  Google Scholar 

  • Perry, H. M., Jr. &Schroeder, H. A. (1954) Syndrome simulating collagen disease caused bythydralazine (Apreoline).JAMA 154:670–673.

    Google Scholar 

  • Peterson, P. &Lund, J. (1969) Systemic lupus erythematosus following thymectomy for myasthenia gravis.Danish Med. Bull. 16:179–181.

    PubMed  Google Scholar 

  • Pollack, A. D. (1959) Some observations on the pathology of systemic lupus erythematosus. InBaehr, G. &Klemperer, P., editors,Systemic Lupus Erythematosus, Crune and Stratton, New York. pp. 1–16.

    Google Scholar 

  • Quichaud, J., Le Bozec, R., Frison, B., Galez, A., Massy, B., etBlanchard, J. (1969) Syndrome candidose Hypoparathyroidie Insuffisance surrénale idiopathique chez un garcon de 10 ans.Ann. D'Endocrinologie 30:682–695

    Google Scholar 

  • Rundle, L. G. &Sparks, F. P. (1963) Thymoma and Dermatomyositis.Arch. Pathol. 75:276–283.

    PubMed  Google Scholar 

  • Russell, P. W., Haserick, J. R. &Zucker, E. M. (1951) Epilepsy in systemic lupus erythematosus; effect of cortisone and ACTH.Arch. Int. Med. (Chicago) 88:78–92.

    Google Scholar 

  • Schottenfield, D. (1970) Medical syndromes associated with malignant tumors.Ca-A Cancer J. for Clinicians 20:35–43.

    Google Scholar 

  • Sheard, C. &Knoepfler, P. T. (1956) Dermatomyositis and the incidence of associated malignancy.Conn. Med. 20:626-.

    PubMed  Google Scholar 

  • Slater, E. &Beard, A. W. (1963) The schizophrenia-like psychosis of epilepsy.Brit. J. Psychiat. 109:95–150.

    PubMed  Google Scholar 

  • Snell, J. F. (1960) Relationship of chromium phosphate clearance rats to resistance. I. The effects of some corticosteroids on blood clearance rats in mice. InHeller, John D., Reticuloendothelial Structure and Function, The Roland Press Co., New York, pp. 321–332.

    Google Scholar 

  • Stern, K. &Wilheim, R. (1948) The biochemistry of malignant tumors; section 8,Immunology Reticuloendothelial System, pp. 629–745, Brooklyn, N. Y., Chemical Publishing Co.

    Google Scholar 

  • Sutphin, A., Albright, F., &Mc Cune, P. J. (1943) Five cases (Three in Syblings) of idiopathic hypoparathryroidism associated with moniliasis.J. Clin. Endocrinol 3:625–634

    Google Scholar 

  • Thibierge, G. &Weissenbach, R. J. (1911) Conretions calcaires sous-cutanées et sclerodermie.Ann. Derm. Syph. (Paris) 2:129–155.

    Google Scholar 

  • Thompson, R. B. (1961) Haematology.J. B. Lippincott Company, Philadelphia.

    Google Scholar 

  • Williams, R. C. (1959) Dermatomyositis and malignancy.Ann. Intern. Med. 50:1174–1181.

    PubMed  Google Scholar 

  • Wolf, J. K., Gokeen, M. &Good, R. A. (1963) Heredo-familial disease of the mesenchymal tissue. Clinical and laboratory study of one family.J. of Lab. and Clinic. Med. 61:230–248.

    Google Scholar 

  • Zatuchni, J. Campbell, W. N. &Zarafonetis, C. J. D. (1953) Pulmonary fibrosis and terminal bronchiolar carcinoma in scleroderma.Cancer 6:1147–1158.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Western Institute for Cancer and Leukemia Research Santa Monica, 90404, California

    Z. Thaddeus Mankowski M. D.

Authors
  1. Z. Thaddeus Mankowski M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported partially byDora Kaplan, Joan Sloan, Memorial Funds and the Roon Foundation.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thaddeus Mankowski, Z. Occurrence of lymphomas and lupus erythematosus-like syndrome in the course of experimental Candida albicans infection in mice. Mycopathologia et Mycologia Applicata 47, 167–182 (1972). https://doi.org/10.1007/BF02126164

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02126164

Keywords

Search

Navigation