Skip to main content
Log in

Virulence of Trichophyton mentagrophytes infecting steroid-treated guinea pigs

  • Published:
Mycopathologia et mycologia applicata Aims and scope Submit manuscript

Abstract

The skin of steroid-treated and normal guinea pigs was inoculated with Trichophyton mentagrophytes and the clinical infection was observed. Organisms isolated from these two groups of animals were cultured on Mycosel® agar and inoculated into untreated guinea pigs to obtain a new infection. In vitro growth inhibition studies were also performed on these organisms using a tolnaftate disc. The character and duration of infection, colonial growth, new infection and tolnaftate inhibition were essentially the same for both the steroid-treated and control groups of animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Boardman, C. R. &Malkinson, F. D. (1962) Tinea versicolor in steroidtreated patients.Arch. Derm. 85:44.

    PubMed  Google Scholar 

  2. Burke, R. C. (1961) Tinea versicolor: susceptibility factors and experimental infection in human beings.J. Invest. Derm. 36:389.

    PubMed  Google Scholar 

  3. Burns, R. E. (1958) Fungous disease as a complication of steroid therapy.Arch. Derm. 77:686.

    Google Scholar 

  4. Canizares, O., Shatin, H. &Kellert, A. (1959) Cushing's syndrome and dermatomycosis.Arch. Derm. 80:705.

    PubMed  Google Scholar 

  5. Caplan, R. M. (1967) Steroid therapy and opportunistic fungal infection. Derm. Digest pp. 29–38. Feb.

  6. Caplan, R. M. &Clabaugh, W. (1969) The influence of corticosteroids, griseofulvin and tolnaftate on the in vitro growth of two dermatophytes.J. Invest. Derm. 52:247.

    PubMed  Google Scholar 

  7. Cremer, G. (1955) The influence of adrenocortical hormones on dermatomycoses, especially in the Cushing syndrome.Dermatologica 111:285.

    PubMed  Google Scholar 

  8. Fisher, M. (1971) The effect of corticosteroids on serum fungistatic activity.Mycopath. Mycol. Appl. 44:241.

    Google Scholar 

  9. Goss, W. A., Actor, P., Jambor, W. P. &Pagano, J. F. (1963) The Trichophyton mentagrophytes andMicrosporum canis infection of the guinea pig.J. Invest. Derm. 40:299.

    PubMed  Google Scholar 

  10. Kligman, A. M., Baldridge, G. D., Rebell, G. &Pillsbury, D. M. (1951) The effect of cortisone on the pathologic responses of guinea pigs infected cutaneously with fungi, viruses and bacteria.J. Lab. Clin. Med. 37:615.

    PubMed  Google Scholar 

  11. Nelson, L. M. &McNiece, K. J. (1959) Recurrent Cushing's syndrome withTrichophyton rubrum infection.Arch. Derm. 80:700.

    PubMed  Google Scholar 

  12. Pillsbury, D. M. &Jacobson, C. (1959) Cushing's syndrome complicated by generalizedTrychophyton rubrum infection.Arch. Derm. 67:436.

    Google Scholar 

  13. Reiss, F. (1949) Steroid hormones: their fungistatic and genestatic effect on pathogenic fungi.Arch. Derm. 59:405.

    Google Scholar 

  14. Sternberg, T. H., Tarbet, J. E., Newcomer, V. D. &Winer, L. H. (1952) Deep infection of mice withTrichophyton rubrum.J. Invest. Derm. 19:373.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fisher, M., Sher, A.M. Virulence of Trichophyton mentagrophytes infecting steroid-treated guinea pigs. Mycopathologia et Mycologia Applicata 47, 121–127 (1972). https://doi.org/10.1007/BF02126159

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02126159

Keywords

Navigation