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Susceptibility of hamsters and mice to Paracoccidioides brasiliensis using different routes of inoculation

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Abstract

Experiments were made to investigate the efficacy of inoculation of hamsters and mice by different routes, for the recovery of the mycelial phase ofParacoccidioides brasiliensis. A clear superiority was found for the intratesticular route in hamsters over the intraperitoneal route in the same animal and also over the intraperitoneal and intravenous routes in mice. The intratesticular route in hamsters is thought to be the most appropriate to be used in future attempts to isolateP. brasiliensis from nature.

Resumen

Se realizaron experiencias tendientes a comparar la eficacia de la inoculación de hamsters y lauchas por diferentes vías, para la recuperación de la fase miceliana deParacoccidioides brasiliensis. Se encontró una clara superioridad de la vía intratesticular en el hamster sobre la vía intraperitoneal en el mismo animal y también sobre las vías intraperitoneal e intravenosa en la laucha.

La vía intratesticular en el hamster se supone indicada para ser usada en la búsqueda del hongo en sus habitats naturales.

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Author notes

  1. I. A. Conti-Díaz (World Health Organization Research Fellow)

    Present address: Departamento de Parasitología (Micología), Instituto de Higiene, Montevideo, Uruguay

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    1. I. A. Conti-Díaz
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    2. M. L. Furcolow
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    Additional information

    From the Department of Community Medicine, Mycology Program, University of Kentucky, College of Medicine, Lexington, Kentucky, 40506, U.S.A.

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    Conti-Díaz, I.A., Furcolow, M.L. Susceptibility of hamsters and mice to Paracoccidioides brasiliensis using different routes of inoculation. Mycopathologia et Mycologia Applicata 47, 73–79 (1972). https://doi.org/10.1007/BF02126155

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    • DOI: https://doi.org/10.1007/BF02126155

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