Cardiovascular Drugs and Therapy

, Volume 1, Issue 1, pp 45–50 | Cite as

Onset of action of captopril, enalapril, enalaprilic acid and lisinopril in normal man

  • P. F. Semple
  • A. M. M. Cumming
  • P. A. Meredith
  • J. J. Morton
Focussed Section: ACE Inhibitors


The effects of orally administered captopril, enalapril and lisinopril on plasma concentrations of angiotensin converting enzyme (ACE), angiotensin II (ANGII) and renin (PRC) were studied over a period of 6 hours in 6 normal subjects. A further 4 subjects received intravenous enalapril and enalaprilic acid (enalaprilat). Captopril (25 mg) by mouth caused a fall in pANGII that reached a nadir 30 to 40 minutes after administration but an effect was hardly apparent after 6 hours. Enalapril (10 mg) by mouth had less marked effects on pACE and pANGII with a decline in levels first apparent 1 hour after administration and the lowest levels reached between 3 and 6 hours. Lisinopril (10 mg) produced a progressive fall in pACE and pANGII from 1 hour to reach the lowest values 6 hours after treatment. Intravenous enalaprilat (5 mg) produced an immediate sustained fall in both pACE and pANGII but intravenous enalapril (7 mg) had a biphasic inhibitory effect.

Key words

ACE inhibitors captopril enalapril enalaprilic acid lisinopril angiotensin II 


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Copyright information

© Martinus Nijhoff Publishing 1987

Authors and Affiliations

  • P. F. Semple
    • 1
  • A. M. M. Cumming
    • 1
  • P. A. Meredith
    • 1
    • 2
  • J. J. Morton
    • 1
  1. 1.MRC Blood Pressure UnitWestern InfirmaryGlasgow
  2. 2.University Department of Materia MedicaStobhill HospitalGlasgow

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