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Medical Microbiology and Immunology

, Volume 169, Issue 4, pp 281–289 | Cite as

Interferon induces an antiviral state in ganglioside-deficient transformed mouse fibroblasts

  • D. Schiffmann
  • K. Koschel
Article

Abstract

The antiviral activity of mouse fibroblast interferon against vesicular stomatitis virus was investigated in L-929 mouse fibroblasts and the ganglioside-deficient L-929 mutant cells (ATCC clone NCTC 2071). Although it has been widely reported that gangliosides serve as primary receptors for interferon at the cellular membrane, only a small difference in interferon sensitivity was observed between the wild-type L-929 and the ganglioside-deficient NCTC 2071 cells. It was not possible, however, to overcome this difference by administration of exogenous gangliosides.

Keywords

Interferon Small Difference Antiviral Activity Cellular Membrane Mutant Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • D. Schiffmann
    • 1
  • K. Koschel
    • 1
  1. 1.Institut für Virologie und Immunobiologie der Universität WürzburgWürzburgFederal Republic of Germany

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