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Bedeutung der Laboratoriumsanalysen bei Sarkoidose

Significance of laboratory analyses in sarcoidosis

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Beiträge zur Klinik und Erforschung der Tuberkulose und der Lungenkrankheiten Aims and scope Submit manuscript

Abstract

Authors are presenting the results of hematologic, BSR, hexosamin, plasma protein and tuberculin analysis of 287 sarcoid patients. In 32.5 per cent they observed leucopenia and in 19 per cent leucocytosis. Monocytosis was present in 29.6 per cent and eosinophilia in 21.2 per cent. The BSR was accelerated in 21.8 per cent, which expressed not truely the activity of the process. The hexosamin content of blood serum is a more sensible indicator of activity than the BSR. In 67 per cent of the 140 patients, in whom the BSR was less than 15 mm/h, the hexosamin content was increased. According to the paper-electrophoretic analysis the albumin fraction was in 81,5 per cent of the cases decreased. In the majority of cases the gradual increase of globulin fractions could be observed. Skin test with tuberculin was performed in 254 patients. In 57.9 per cent they obtained a negative result.

Zusammenfassung

Die Verfasser berichten über die hämatologischen BSG-, Hexosamin-, Plasmaprotein- und Tuberkulinuntersuchungsergebnisse bei 287 Sarkoidosepatienten. In 32,5% fanden sie eine Leukopenie, in 19% Leukocytose. In 29,6% kam eine Monocytose und in 21,2% Eosinophilie vor. Die BSG war nur in 21,8% der Fälle stark beschleunigt, und dies brachte die Aktivität des Prozesses nicht genügend zum Ausdruck. Der Hexosamingehalt des Blutserums ist ein empfindlicherer Indicator der Aktivität als die BSG. Unter 140 Kranken, bei denen die BSG weniger als 15 mm/St. betrug, erhielten sie in 67% einen erhöhten Hexosamingehalt. Nach den papierelektrophoretischen Untersuchungen war die Albuminfraktion in 81,5% vermindert. In überwiegender Mehrzahl der Fälle konnte eine graduelle Zunahme der Globulinfraktionen beobachtet werden. Eine Tuberkulinimpfung erfolgte in 254 Fällen, 57,9% der Kranken war Tuberkulinnegativ.

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Authors and Affiliations

  1. Lungenklinik der Medizinischen Universität Debrecen, Hungary

    Sándor Vezendi, László Mándi, Erzsébet Fábián & Erzsébet Jankó

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  1. Sándor Vezendi
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Vezendi, S., Mándi, L., Fábián, E. et al. Bedeutung der Laboratoriumsanalysen bei Sarkoidose. Beitr. Klin. Tuberk. 141, 311–318 (1970). https://doi.org/10.1007/BF02125316

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