Medical Microbiology and Immunology

, Volume 173, Issue 5, pp 279–289 | Cite as

Antibiotics and immunomodulation: Effects of cefotaxime, amikacin, mezlocillin, piperacillin and clindamycin

  • W. Roszkowski
  • H. L. Ko
  • K. Roszkowski
  • J. Jeljaszewicz
  • G. Pulverer


The effects of 7 days' chemotherapy on the humoral and cellular parameters of the host immune system are described. In Balb/c mice the effects of cefotaxime, amikacin, mezlocillin, piperacillin and clindamycin were examined. The delayed-type hypersensitivity reaction, as well as the IgM and IgG responses, were suppressed by four of the five drugs tested: cefotaxime, amikacin, mezlocillin and piperacillin. One to two weeks after completion of chemotherapy with cefotaxime and amikacin, these parameters returned to normal values, whereas the mezlocillinor piperacillin-modified reactions were still suppressed after 20 days. The concanavalin A and lipopolysaccharide-induced proliferative activities of mouse spleen cells were suppressed, especially by mezlocillin. The possible consequences of the immunomodulating effects of antibiotics for antimicrobial chemotherapy are discussed.


Immune System Cefotaxime Hypersensitivity Reaction Proliferative Activity Clindamycin 
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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • W. Roszkowski
    • 1
  • H. L. Ko
    • 2
  • K. Roszkowski
    • 1
  • J. Jeljaszewicz
    • 3
  • G. Pulverer
    • 2
  1. 1.National Institute of Lung Diseases and TuberculosisWarsawPoland
  2. 2.Institute of HygieneUniversity of CologneFederal Republic of Germany
  3. 3.National Institute of HygieneWarsawPoland

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