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Medical Microbiology and Immunology

, Volume 173, Issue 5, pp 279–289 | Cite as

Antibiotics and immunomodulation: Effects of cefotaxime, amikacin, mezlocillin, piperacillin and clindamycin

  • W. Roszkowski
  • H. L. Ko
  • K. Roszkowski
  • J. Jeljaszewicz
  • G. Pulverer
Article

Abstract

The effects of 7 days' chemotherapy on the humoral and cellular parameters of the host immune system are described. In Balb/c mice the effects of cefotaxime, amikacin, mezlocillin, piperacillin and clindamycin were examined. The delayed-type hypersensitivity reaction, as well as the IgM and IgG responses, were suppressed by four of the five drugs tested: cefotaxime, amikacin, mezlocillin and piperacillin. One to two weeks after completion of chemotherapy with cefotaxime and amikacin, these parameters returned to normal values, whereas the mezlocillinor piperacillin-modified reactions were still suppressed after 20 days. The concanavalin A and lipopolysaccharide-induced proliferative activities of mouse spleen cells were suppressed, especially by mezlocillin. The possible consequences of the immunomodulating effects of antibiotics for antimicrobial chemotherapy are discussed.

Keywords

Immune System Cefotaxime Hypersensitivity Reaction Proliferative Activity Clindamycin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Banck G, Forsgren A (1979) Antibiotics and suppression of lymphocyte function in vitro. Antimicrob Agents Chemother 16:554–560PubMedGoogle Scholar
  2. 2.
    Blanke TJ, Little JR, Shirley SF, Lynch RG (1977) Augmentation of murine immune responses by amphotericin B. Cell Immunol 33:180–190CrossRefPubMedGoogle Scholar
  3. 3.
    Dam WC, Malkinson FD, Gewurtz H (1975) The effect of common antibiotics on lymphocyte transformation. Experientia 31:375–376CrossRefPubMedGoogle Scholar
  4. 4.
    Finch R (1980) Immunomodulating effects of antimicrobial agents. J Antimicrob Chemother 6:691–699PubMedGoogle Scholar
  5. 5.
    Forsgren A, Schmeling D, Quie PG (1974) Effects of tetracyclines on phagocytic function of human leukocytes. J Infect Dis 130:422Google Scholar
  6. 6.
    Gillissen GJ (1982) Influence of cephalosporins on humoral immune response. In: Eickenberg HL, Hahn H, Opferkuch W (eds) The influence of antibiotics on the host-parasite relationship. Springer-Verlag, Berlin, Heidelberg, New York, pp 5–11Google Scholar
  7. 7.
    Hauser WE, Remington JS (1982) Effect of antibiotics on the immune response. Am J Med 72:711–716CrossRefPubMedGoogle Scholar
  8. 8.
    Little JR, Blanke TJ, Valeriote F, Madolff G (1978). Immunoadjuvant and anti-tumor properties of amphotericin B. In: Chirigos MA (ed) Immune modulation and control of neoplasia by adjuvant therapy. Raven Press, New York, pp 381–387Google Scholar
  9. 9.
    Milatovic D (1983) Antibiotics and phagocytosis. Eur J Clin Microbiol 2:414–425CrossRefPubMedGoogle Scholar
  10. 10.
    Paunescu E (1970) In vivo and in vitro suppression of humoral and cellular immunological response by rifampicin. Nature 228:1188–1190CrossRefPubMedGoogle Scholar
  11. 11.
    Peterson PK (1982) How antibiotics augment host defenses. Eur J Clin Microbiol 1:335–337CrossRefPubMedGoogle Scholar
  12. 12.
    Roselle GA, Kauffman CA (1980) Amphotericin B and 5-fluorocytosine effect on cell-mediated immunity. Clin Exp Immunol 40:186–192PubMedGoogle Scholar
  13. 13.
    Roszkowski K, Ko HL, Roszkowski W, Jeljaszewicz J, Pulverer G (1984) Effect of some antibiotics on sarcoma L-1 tumor growth in mice. Zentralbl Bakteriol Mikrobiol Hyg [A] (in press)Google Scholar
  14. 14.
    Roszkowski W, Lipinska R, Roszkowski K, Jeljaszewicz J, Pulverer G (1984) Rifampicin induced suppression of antitumor immunity. Med Microbiol Immunol 172:197–205CrossRefPubMedGoogle Scholar
  15. 15.
    Thong YH, Ferrante A (1979) Inhibition of mitogen-induced human lymphocyte proliferative response to tetracycline analogues. Clin Exp Immunol 35:443–446PubMedGoogle Scholar
  16. 16.
    Thong YH, Ferrante A (1980) Effects of tetracycline treatment on immunological responses in mice. Clin Exp Immunol 39:728–732PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • W. Roszkowski
    • 1
  • H. L. Ko
    • 2
  • K. Roszkowski
    • 1
  • J. Jeljaszewicz
    • 3
  • G. Pulverer
    • 2
  1. 1.National Institute of Lung Diseases and TuberculosisWarsawPoland
  2. 2.Institute of HygieneUniversity of CologneFederal Republic of Germany
  3. 3.National Institute of HygieneWarsawPoland

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