Disorders of neutrophil function in children with recurrent pyogenic infections
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Ten patients with neutrophil dysfunctions and recurrent pyogenic infections, mainly of the skin, middle ear, and respiratory tract, are described. The most frequently affected functions were chemotaxis and bacterial killing. Pharmacologic restoration of functional defects was tried in all cases. Levamisole was given in two cases and ascorbic acid in the other eight cases. During a follow up of at least 18 months, seven patients showed a complete restoration of neutrophil function and a long-lasting clinical remission. One of the two patients with Chronic Granulomatous Disease has been free from infections for 1 year, despite persistent neutrophil dysfunction, while the other did not display consistent clinical improvement. Another patient, who was given ascorbic acid for a short period only due to non compliance, showed neither laboratory nor clinical improvement.
KeywordsAscorbic Acid Respiratory Tract Clinical Improvement Clinical Remission Levamisole
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- Clark RA (1978) Disorders of granulocyte chemotaxis. In: Leukocyte chemotaxis: methods, physiology and clinical implications (eds. Gallin JI and Quie PG) pp. 329–356. Raven Press, New YorkGoogle Scholar
- Dallegri F, Lanzi G, Patrone F (1980) Effects of ascorbic acid on neutrophil locomotion. Int Archs Allergy appl Immun 61:40–45Google Scholar
- Gabig TG (1980) Leukocyte abnormalities. Med Clin North Amer 64:647–666Google Scholar
- Nonoyama S, Kojo H, Mine Y, Nishida M, Goto S, Kuwahara S (1979) Inhibitory effect of Pseudomonas aeruginosa on the phagocytic and killing activities of rabbit polymorphonuclear leukocytes: purification and characterization of an inhibitor of polymorphonuclear leukocyte function. Infect Immun 24:394–399PubMedGoogle Scholar
- Patrone F, Dallegri F, Bonvini E, Sacchetti C (1980) In vitro effects of synthetic chemotactic peptides on neutrophil function. Int Archs Allergy appl Immun 62:316–323Google Scholar
- Quie PG, Cates KL (1978) Clinical manifestations of disorders of neutrophil chemotaxis. In: Leukocyte chemotaxis: methods, physiology and clinical implications (eds. Gallin JI and Quie PG) pp. 307–324, Raven Press, New YorkGoogle Scholar
- Solberg CO (1972) Evaluation of neutrophil granulocyte function. Acta Path Microbiol Scand B 80:559–563Google Scholar
- Wilkinson PC (1974) Chemotaxis and inflammation. Churchill Livingstone, Edinburgh and LondonGoogle Scholar