Abstract
Previous virological and immunological studies have suggested that multiple sclerosis (MS) is an auto-immune disease triggered by a virus infection. In order to inhibit the growth of measles virus in the patient's jejunum, we obtained an IgA-rich cow colostrum containing anti-measles lactoglobulin resistant to proteases. This colostrum was orally administered to patients with MS to investigate its effect on the course of the disease.
Measles-positive antibody colostrum was orally administered every morning to 15 patients with MS at a daily dosage of 100 ml for 30 days. Similarly, measles-negative antibody (< 8) control colostrum was orally administered to 5 patients. As a clinical assessment, disability scores developed by the International Federation of Multiple Sclerosis Societies were used. As a result, of 7 high NT titre (512–5120) anti-measles colostrum recipients 5 patients improved and 2 remained unchanged. Among 8 low NT titre (8–32) anti-measles colostrum recipients 5 patients improved and 3 remained unchanged. However, of 5 negative NT titre (< 8) colostrum recipients 2 patients remained unchanged and 3 worsened. No side-effects were observed in colostrum recipients. These findings suggest the efficacy of orally administered anti-measles colostrum in improving the condition of MS patients (P < 0.05).
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Bluestein HG, Zeigler NJ (1975) Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus. J Clin Invest 57:509–516
Bresnihan B, Oliver M, Grigor R, Hughes GRV (1977) Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with or without cerebral involvement. Clin Exp Immunol 30:333–337
Ebina T, Tsukamoto T, Suzuki H, Takase S, Itahara K, Ishida N (1979) Measles virus in jejunum of patients with multiple sclerosis. Lancet I:99
Ebina T, Sato A, Umezu K, Ishida N, Ohyama S, Oizumi A, Aikawa K, Katagiri S, Katsushima N, Imai A, Kitaoka S, Suzuki H, Konno T (1983) Prevention of rotavirus infection by cow colostrum containing antibody against human rotavirus. Lancet II:1029–1030
Jacobs L, O'Malley, J, Freeman A, Ekes R (1981) Intrathecal interferon reduces exacerbations of multiple sclerosis. Science 214:1026–1028
Mertin J, Rudge P, Kremer M, Healey MJR, Knight SC, Compston A, Batchelor JR, Thompson EJ, Halliday AM, Denman M, Medawar PB (1982) Double-blind controlled trial of immunosuppression in the treatment of multiple sclerosis: final report. Lancet II:351–353
Prasad I, Broome JD, Pertschuk LP, Gupta J, Cook AW (1977) Recovery of paramyxovirus from the jejunum of patients with multiple sclerosis. Lancet I:1117–1118
Schumacher GA, Beebe G, Kibler RF (1965) Problems of experimental trials of therapy in multiple sclerosis: Report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann N Y Acad Sci 122:552–568
Sullivan JL, Barry DW, Lucas SL, Albrecht P (1975) Measles infection of human mononuclear cells I. Acute infection of peripheral blood lymphocytes and monocytes. J Exp Med 142:773–784
Tsukamoto T, Ebina T, Takase S, Itahara K, Ishida N (1982) Increased frequency of lymphocytotoxic antibodies in patients with multiple sclerosis correlated with disease activity. Tohoku J Exp Med 136:121–128
Watanabe R, Wege H, ter Meuler V (1983) Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis. Nature 305:150–153
Winfield JB, Winchester RJ, Wernet P, Fu SM, Kunkel MG (1975) Nature of cold reactive antibodies to lymphocyte surface determinants in systemic lupus erythematosus. Arthritis Rheum 18:1–8
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Ebina, T., Sato, A., Umezu, K. et al. Treatment of multiple sclerosis with anti-measles cow colostrum. Med Microbiol Immunol 173, 87–93 (1984). https://doi.org/10.1007/BF02124822
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DOI: https://doi.org/10.1007/BF02124822