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Die Durchseuchung der Bevölkerung mit dem im Tierversuch kanzerogenen Adenovirus Typ 18

  • Ch. Tauchnitz
  • H. -P. Keller
Article

Zusammenfassung

565 menschliche Seren aller Altersstufen wurden in der Verdünnung 1∶10 auf neutralisierende Antikörper gegen Adenovirus Typ 18 untersucht. Insgesamt zeigten 36% eine partielle oder vollständige neutralisierende Wirkung, wobei gewisse Schwankungen innerhalb der einzelnen Altersgruppen bestanden. Bei 131 Seren erfolgte zusätzlich die Untersuchung in der Verdünnung 1∶5. Hierbei ergaben sich wesentlich höhere Durchseuchungszahlen, die bei den 16 bis 40jährigen 84% der geprüften Seren erreichten. Daraus wird auf eine ubiquitäre Verbreitung des Virus in der Bevölkerung geschlossen. Es besteht deshalb kein Grund, den im Tierversuch schwächer Tumor-wirksamen Adenovirustypen 3 und 7 eine größere Bedeutung als mögliche Erreger menschlicher Tumoren allein wegen ihrer weiten Verbreitung in der Bevölkerung zuzuerkennen. Seren mit höheren Titern wurden nur vereinzelt gefunden. Sie erreichten maximal einen Wert von 1∶80. Hieraus wird auf eine relativ geringe Antigenität des Adenovirus Typ 18 für den Menschen geschlossen.

Summary

565 human sera of all age groups were tested for neutralizing antibodies against adenovirus type 18 in a 1∶10 dilution. Totally in 36% a partial or complete neutralisation was seen, varieting within the age groups. 131 sera were also tested in a 1∶5 dilution, resulting a much higher proportion of sera with antibodies: 84% of the 16–40 years old persons. Therefore there is no reason to contribute the adenovirus types 3 or 7 a higher probability as causative agents of human malignancies because of their distribution in the population.

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Copyright information

© Springer-Verlag 1967

Authors and Affiliations

  • Ch. Tauchnitz
    • 1
  • H. -P. Keller
    • 1
  1. 1.Institut für Medizinische Mikrobiologie und Epidemiologie der Karl Marx-Universität LeipzigDeutschland

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