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Alterations in serum proteins of rats after immunization with Freund's adjuvant andBordetella pertussis vaccine

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Abstract

Immunization is known to modify the level of certain circulating serum proteins. In this study we describe changes in the electrophoretic pattern of serum proteins after immunization with two different antigens: RaTE and BSA incorporated with three different adjuvants: complete Freund's adjuvant, incomplete Freund's adjuvant, andBordetella pertussis vaccine. Serum albumin andγ globulins were decreased whileα 1, α2, andΒ globulins had a tendency to increase. The serum protein modifications were observed as early as 24 h after immunization and were not reversed by histamine or serotonin antagonists. Some physiopathological hypotheses of their possible effects in immunization are discussed.

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Author notes

  1. Micheline Pelletier (Recipient of a Fellowship from the Medical Research Council of Canada) & Serge Montplaisir (Recipient of a Fellowship from the Medical Research Council of Canada)

    Present address: Clinique Néphrologique, HÔpital Necker, 161, rue de Sèvres, 75730, Paris Cedex 15, France

  2. Noel R. Rose

    Present address: Dept. of Immunology and Microbiology, Wayne State University School of Medicine Gordon H. Scott Hall of Basic Medical Sciences, 540 East Canfield Avenue, 48201, Detroit, Michigan, USA

Authors and Affiliations

  1. Center for Immunology and Departments of Microbiology and Medicine, State University of New York at Buffalo, School of Medicine, Buffalo, N. Y.

    Micheline Pelletier (Recipient of a Fellowship from the Medical Research Council of Canada), Serge Montplaisir (Recipient of a Fellowship from the Medical Research Council of Canada) & Noel R. Rose

  2. Dept. of Immunology and Microbiology, Wayne State University School of Medicine, 540 E. Canfield, 48201, Detroit, Michigan, USA

    Noel R. Rose

Authors
  1. Micheline Pelletier
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  2. Serge Montplaisir
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  3. Noel R. Rose
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Additional information

This study was supported by PHS Research Grant CA 02357 from the National Cancer Institute. It is publication no 75 from the Center for Immunology.

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Pelletier, M., Montplaisir, S. & Rose, N.R. Alterations in serum proteins of rats after immunization with Freund's adjuvant andBordetella pertussis vaccine. Med Microbiol Immunol 160, 9–21 (1974). https://doi.org/10.1007/BF02124339

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  • DOI: https://doi.org/10.1007/BF02124339

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