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Demonstration of a tryptaminergic mechanism in the ratβ-cell


Yellow 5-HT fluorescence has been histochemically demonstrated in rat pancreatic islet cells in animals injected with L-5-HTP with or without pretreatment with the monoaminoxidase inhibitor nialamide. This fluorescence was not observed after inhibition of the aromatic amino acid decarboxylase. The results strongly suggest the presence of a tryptaminergic mechanism in the rat islet cells.

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This work was supported by the Medical Research Council of Canada.

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Pulido, O., de Bold, A., de Bold, M. et al. Demonstration of a tryptaminergic mechanism in the ratβ-cell. Experientia 33, 268–270 (1977).

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  • Islet Cell
  • Pancreatic Islet
  • Aromatic Amino Acid
  • Acid Decarboxylase
  • Monoaminoxidase Inhibitor