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Experientia

, Volume 33, Issue 2, pp 253–254 | Cite as

Acidic metabolite of prednisolone

  • H. J. Lee
Article

Summary

The metabolic fate of the 17β-ketol side chain of (21-3H) prednisolone was studied with an enzyme preparation from male golden hamster liver. The acidic metabolite of prednisolone was identified by mass spectrometry as 11β, 17α,20ξ-trihydroxy-3-oxo-1,4-pregnadien-21-oic acid. The enzyme showed substrate specificity, depending on the nature of substituent on the steroid nucleus.

Keywords

Enzyme Mass Spectrometry Steroid Prednisolone Substrate Specificity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • H. J. Lee
    • 1
  1. 1.School of PharmacyFlorida Agricultural and Mechanical UniversityTallahasseeUSA

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