, Volume 33, Issue 2, pp 224–226 | Cite as

The effect of cobra venom factor (CVF) activation of the complement cascade on leukocyte circadian variation in the rat

  • Phillip C. Hoopes
  • Charles E. McCall


Administration of cobra venom factor (CVF) at different time periods over a 24-h-period produced a leukocytic response which varied according to the time of day the factor was given. The resulting leukocytic circadian rhythm was achieved by a marked variation and increase in the neutrophil population.


Circadian Rhythm Marked Variation Circadian Variation Complement Cascade Cobra Venom 
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  1. 2.
    H. J. Muller-Eberhard, in: Progress in Immunology. Ed. B. Amos. Academic Press, New York 1971.Google Scholar
  2. 3.
    S. Ruddy, I. Gigli and F. Austen, New Engl. J. Med.287, 489 (1972).PubMedGoogle Scholar
  3. 4.
    C. E. McCall, L. R. DeChatelet, D. Brown and P. Lachmann, Nature249, 841 (1974).PubMedGoogle Scholar
  4. 5.
    J. E. Pauly and L. E. Scheving, Anat. Rec.153, 349 (1965).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • Phillip C. Hoopes
    • 1
  • Charles E. McCall
    • 1
  1. 1.Department of Medicine, Bowman Gray School of MedicineWake Forest UniversityWinston-SalemUSA

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