Abstract
A single dose of a commercial trivalent influenza subunit vaccine (SV) and two whole virus vaccines (WVV) were compared in a randomized, placebo-controlled field trial of subjects under 23 years of age in the Israel Defence Forces. Sixty percent of SV recipients and 29% and 37% of WVV recipients showed no measurable response to the H1N1 subtype (A/USSR). When the prevaccination titer to H1N1 was <10, SV did not differ significantly from the placebo, and when ⩾10, the SV was poorer than the WVV. Response to the H3N2 (A/Texas) component was excellent, but when the prevaccination titer was <10, SV appeared less immunogenic than WVV. All three vaccines performed equally against the B/Hong Kong strain.
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Kark, J.D., Lebiush, M., Rannon, L. et al. The antigenicity of whole virus versus subunit trivalent influenza vaccines — a field trial in the Israel Defence Forces, 1978. Med Microbiol Immunol 170, 55–62 (1981). https://doi.org/10.1007/BF02123797
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DOI: https://doi.org/10.1007/BF02123797