Medical Microbiology and Immunology

, Volume 159, Issue 4, pp 301–308 | Cite as

The protection of mice by a specific anti -Erysipelothrix insidiosa-neuraminidase-antiserum againstErysipelothrix insidiosa infection

  • H. E. Müller


Until now the pathomechanism of the inflammation or septicemia in man and other animals produced byE. insidiosa has been unknown. The discovery of neuraminidase inE. insidiosa suggested the pathogenic role of this enzyme. The following experiment supports this notion.

E. insidiosa neuraminidase was isolated and purified. A specific anti-E. insidiosa-neuraminidase-antiserum was produced in a rabbit. This antiserum protected mice against a normally fatalE. insidiosa infection with statistical significance (P<0.007 respectivelyP<0.002).

Therefore neuraminidase is an important pathogenic factor inE. insidiosa infection. Blocking of this enzyme with antiserum effects the loss of pathogenicity ofE. insidiosa.


Pathogenic Role Pathogenic Factor Important Pathogenic Factor 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • H. E. Müller
    • 1
  1. 1.Institut für Medizinische Mikrobiologie und Immunologie der UniversitÄt BonnDeutschland

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